BPZE1 vaccination induces IL-17+ and IL-22+ CD4+ T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation.
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| Title: | BPZE1 vaccination induces IL-17+ and IL-22+ CD4+ T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation. |
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| Authors: | Hill AR; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Gbesemete DF; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Coutinho T; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Ibrahim M; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Laver JR; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Goldstein P; ILiAD Biotechnologies, Weston, FL, USA., Noviello S; ILiAD Biotechnologies, Weston, FL, USA., Rubin K; ILiAD Biotechnologies, Weston, FL, USA., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Locht C; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL - Centre for Infection and Immunity of Lille, Lille, France., Read RC; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Dale AP; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. a.p.dale@soton.ac.uk.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. a.p.dale@soton.ac.uk. |
| Source: | NPJ vaccines [NPJ Vaccines] 2026 Apr 18; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42000798 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: BPZE1 vaccination induces IL-17<superscript>+</superscript> and IL-22<superscript>+</superscript> CD4<superscript>+</superscript> T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hill+AR%22">Hill AR</searchLink>; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Gbesemete+DF%22">Gbesemete DF</searchLink>; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Coutinho+T%22">Coutinho T</searchLink>; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Ibrahim+M%22">Ibrahim M</searchLink>; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Laver+JR%22">Laver JR</searchLink>; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Goldstein+P%22">Goldstein P</searchLink>; ILiAD Biotechnologies, Weston, FL, USA.<br /><searchLink fieldCode="AU" term="%22Noviello+S%22">Noviello S</searchLink>; ILiAD Biotechnologies, Weston, FL, USA.<br /><searchLink fieldCode="AU" term="%22Rubin+K%22">Rubin K</searchLink>; ILiAD Biotechnologies, Weston, FL, USA.<br /><searchLink fieldCode="AU" term="%22Faust+SN%22">Faust SN</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Locht+C%22">Locht C</searchLink>; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL - Centre for Infection and Immunity of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Read+RC%22">Read RC</searchLink>; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Dale+AP%22">Dale AP</searchLink>; Controlled Human Infection Group, School of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. a.p.dale@soton.ac.uk.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. a.p.dale@soton.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101699863%22">NPJ vaccines</searchLink> [NPJ Vaccines] 2026 Apr 18; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Apr 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature+in+partnership+with+the+Sealy+Center+for+Vaccine+Development%22">Springer Nature in partnership with the Sealy Center for Vaccine Development </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101699863 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-0105 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220590105%22">20590105 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Vaccines <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42000798 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41541-026-01443-7 Languages: – Code: eng Text: English Titles: – TitleFull: BPZE1 vaccination induces IL-17+ and IL-22+ CD4+ T cells associated with nasal mucosal secretory IgA responses in humans: effects on virulent Bordetella pertussis colonisation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hill AR – PersonEntity: Name: NameFull: Gbesemete DF – PersonEntity: Name: NameFull: Coutinho T – PersonEntity: Name: NameFull: Ibrahim M – PersonEntity: Name: NameFull: Laver JR – PersonEntity: Name: NameFull: Goldstein P – PersonEntity: Name: NameFull: Noviello S – PersonEntity: Name: NameFull: Rubin K – PersonEntity: Name: NameFull: Faust SN – PersonEntity: Name: NameFull: Locht C – PersonEntity: Name: NameFull: Read RC – PersonEntity: Name: NameFull: Dale AP IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 04 Text: 2026 Apr 18 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2059-0105 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: NPJ vaccines Type: main |
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