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Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline.

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Title: Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline.
Authors: Qi W; School of Life Sciences, Shanghai University, Shanghai, China.; Shanghai Institute of Nutrition and Health, Chinese Academy of Science, Shanghai, China., Liu Q; School of Life Sciences, Shanghai University, Shanghai, China., Dong N; School of Life Sciences, Shanghai University, Shanghai, China.; Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China., Sun X; Cancer Institute/Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shangh, China., Wu P; School of Life Sciences, Shanghai University, Shanghai, China., Zhou J; School of Life Sciences, Shanghai University, Shanghai, China., Sun R; School of Life Sciences, Shanghai University, Shanghai, China., Liu Y; Department of General Surgery, Pancreatic Disease Center, Research Institute of Pancreatic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xb88053@sjtu.edu.cn., Zhao RC; School of Life Sciences, Shanghai University, Shanghai, China. zhaochunhua@vip.163.com.; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. zhaochunhua@vip.163.com.; Centre of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences, Beijing, China. zhaochunhua@vip.163.com.; Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy, Beijing, China. zhaochunhua@vip.163.com., Wang J; School of Life Sciences, Shanghai University, Shanghai, China. jo717@shu.edu.cn.; School of Life Science and Technology, Shandong Vocational University of Foreign Affairs, Jinan, China. jo717@shu.edu.cn.; Department of Rehabilitation Medicine, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China. jo717@shu.edu.cn.; Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Northwest Minzu University, Lanzhou, Gansu, China. jo717@shu.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Apr 20; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting ATP11B-YAP axis repairs mitochondrial function and inhibits neuronal ferroptosis to attenuate age-related cognitive decline.
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  Data: <searchLink fieldCode="AU" term="%22Qi+W%22">Qi W</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China.; Shanghai Institute of Nutrition and Health, Chinese Academy of Science, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Dong+N%22">Dong N</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China.; Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Cancer Institute/Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shangh, China.<br /><searchLink fieldCode="AU" term="%22Wu+P%22">Wu P</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+R%22">Sun R</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of General Surgery, Pancreatic Disease Center, Research Institute of Pancreatic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xb88053@sjtu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+RC%22">Zhao RC</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China. zhaochunhua@vip.163.com.; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. zhaochunhua@vip.163.com.; Centre of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences, Beijing, China. zhaochunhua@vip.163.com.; Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy, Beijing, China. zhaochunhua@vip.163.com.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; School of Life Sciences, Shanghai University, Shanghai, China. jo717@shu.edu.cn.; School of Life Science and Technology, Shandong Vocational University of Foreign Affairs, Jinan, China. jo717@shu.edu.cn.; Department of Rehabilitation Medicine, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China. jo717@shu.edu.cn.; Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Northwest Minzu University, Lanzhou, Gansu, China. jo717@shu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2026 Apr 20; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Apr 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41392-026-02652-1
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              Text: 2026 Apr 20
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