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Local Immunometabolic Intervention With Alanyl-Glutamine Resolves Peritoneal Dialysis-Induced Immune Cell Dysfunction.

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Title: Local Immunometabolic Intervention With Alanyl-Glutamine Resolves Peritoneal Dialysis-Induced Immune Cell Dysfunction.
Authors: Herzog R; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Daniel-Fischer L; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Eibensteiner F; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.; Center for Medical Data Science, Institute for Medical Statistics, Medical University of Vienna, Vienna, Austria., Sobieszek IJ; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Unterwurzacher M; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Sacnun JM; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Uhl PKT; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Lang E; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Wagner A; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., König F; Center for Medical Data Science, Institute for Medical Statistics, Medical University of Vienna, Vienna, Austria., Alper SL; Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Davies LC; Faculty of Medicine, Health and Life Science, Swansea University, Swansea, UK., Aufricht C; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Vychytil A; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Kratochwill K; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.
Source: Kidney international reports [Kidney Int Rep] 2026 Feb 02; Vol. 11 (5), pp. 106342. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101684752 Publication Model: eCollection Cited Medium: Internet ISSN: 2468-0249 (Electronic) Linking ISSN: 24680249 NLM ISO Abbreviation: Kidney Int Rep Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Herzog+R%22">Herzog R</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Daniel-Fischer+L%22">Daniel-Fischer L</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Eibensteiner+F%22">Eibensteiner F</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.; Center for Medical Data Science, Institute for Medical Statistics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Sobieszek+IJ%22">Sobieszek IJ</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Peritoneal Regulation of the Immune-Metabolic Ecosystem in Peritoneal Dialysis (CDL-PRIME-PD), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Unterwurzacher+M%22">Unterwurzacher M</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Sacnun+JM%22">Sacnun JM</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Uhl+PKT%22">Uhl PKT</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lang+E%22">Lang E</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wagner+A%22">Wagner A</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22König+F%22">König F</searchLink>; Center for Medical Data Science, Institute for Medical Statistics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Alper+SL%22">Alper SL</searchLink>; Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Davies+LC%22">Davies LC</searchLink>; Faculty of Medicine, Health and Life Science, Swansea University, Swansea, UK.<br /><searchLink fieldCode="AU" term="%22Aufricht+C%22">Aufricht C</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Vychytil+A%22">Vychytil A</searchLink>; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kratochwill+K%22">Kratochwill K</searchLink>; Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.
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