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Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome.

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Title: Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome.
Authors: Fieblinger T; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Rudolph J; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Müller K; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Friess P; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Weigelt N; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Thiede C; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Modolo S; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Federico D; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Majandinow M; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Tinarelli F; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Costantini VJA; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Marrese PP; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Mercuri A; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Carty N; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Gomes AC; PTEN Research, 4th Floor, St James House, St James Square, Cheltenham, Gloucestershire GL50 3PR, UK., Whitehead MA; Maria Whitehead Consulting OY, 00250 Helsinki, Finland., Gerrard PA; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Papadopoulos C; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Elvin P; PTEN Research, 4th Floor, St James House, St James Square, Cheltenham, Gloucestershire GL50 3PR, UK.
Source: IScience [iScience] 2026 Mar 20; Vol. 29 (4), pp. 115428. Date of Electronic Publication: 2026 Mar 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Fieblinger+T%22">Fieblinger T</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rudolph+J%22">Rudolph J</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+K%22">Müller K</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Friess+P%22">Friess P</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Weigelt+N%22">Weigelt N</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thiede+C%22">Thiede C</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Modolo+S%22">Modolo S</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Federico+D%22">Federico D</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Majandinow+M%22">Majandinow M</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tinarelli+F%22">Tinarelli F</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Costantini+VJA%22">Costantini VJA</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Marrese+PP%22">Marrese PP</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mercuri+A%22">Mercuri A</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Carty+N%22">Carty N</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gomes+AC%22">Gomes AC</searchLink>; PTEN Research, 4th Floor, St James House, St James Square, Cheltenham, Gloucestershire GL50 3PR, UK.<br /><searchLink fieldCode="AU" term="%22Whitehead+MA%22">Whitehead MA</searchLink>; Maria Whitehead Consulting OY, 00250 Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Gerrard+PA%22">Gerrard PA</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Papadopoulos+C%22">Papadopoulos C</searchLink>; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Elvin+P%22">Elvin P</searchLink>; PTEN Research, 4th Floor, St James House, St James Square, Cheltenham, Gloucestershire GL50 3PR, UK.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2026 Mar 20; Vol. 29 (4), pp. 115428. <i>Date of Electronic Publication: </i>2026 Mar 20 (<i>Print Publication: </i>2026).
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