Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex.

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Title: Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex.
Authors: Sellitto S; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Caredio D; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Bimbati M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Mariutti G; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Cerisoli M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Frick L; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Bouris V; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Morales COO; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Vena DL; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Neupane S; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Baroni F; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Ging K; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Yin JA; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., De Cecco E; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Armani A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.; Department of Biomedical Sciences, University of Padua, Padova, Italy., Aguzzi A; Institute for the Science of the Aging Brain, St. Gallen, Switzerland.
Source: PLoS pathogens [PLoS Pathog] 2026 Apr 20; Vol. 22 (4), pp. e1014056. Date of Electronic Publication: 2026 Apr 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1553-7374
DOI:10.1371/journal.ppat.1014056