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Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial.

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Title: Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial.
Authors: Melero I; Clínica Universidad de Navarra, CIMA and CIBERONC, Pamplona, Spain.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tanos T; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Calvo Aller E; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain., Qvortrup C; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., van Dongen M; Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, The Netherlands., Baraibar I; Vall d'Hebron Hospital Campus and Institute of Oncology (VHIO), CIBERONC, IR-HUVH, Barcelona, Spain., Beom SH; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea., Thistlethwaite F; The Christie NHS Foundation Trust and University of Manchester, Manchester, UK., Riesco MDC; Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain., Garcia MM; Medical Oncology Department, Hospital del Mar Research Institute, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Woodcock V; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kim TW; Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Umana P; Pharma Research & Early Development, Roche Innovation Center Zurich, Zurich, Switzerland., McIntyre C; Roche Pharma Research & Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, UK., Chen L; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Heichinger C; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Hinton H; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Saylan T; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Davydov II; Computational Sciences Center of Excellence, Roche Innovation Center Basel, Basel, Switzerland., Guarin E; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland., Boehnke A; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland. axel.boehnke@roche.com., Moreno V; START Madrid-FJD, Hospital Fundación Jiménez Díaz, Madrid, Spain.
Source: Nature medicine [Nat Med] 2026 Apr 20. Date of Electronic Publication: 2026 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Melero+I%22">Melero I</searchLink>; Clínica Universidad de Navarra, CIMA and CIBERONC, Pamplona, Spain.; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tanos+T%22">Tanos T</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Calvo+Aller+E%22">Calvo Aller E</searchLink>; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Qvortrup+C%22">Qvortrup C</searchLink>; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22van+Dongen+M%22">van Dongen M</searchLink>; Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Baraibar+I%22">Baraibar I</searchLink>; Vall d'Hebron Hospital Campus and Institute of Oncology (VHIO), CIBERONC, IR-HUVH, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Beom+SH%22">Beom SH</searchLink>; Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Thistlethwaite+F%22">Thistlethwaite F</searchLink>; The Christie NHS Foundation Trust and University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Riesco+MDC%22">Riesco MDC</searchLink>; Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia+MM%22">Garcia MM</searchLink>; Medical Oncology Department, Hospital del Mar Research Institute, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Woodcock+V%22">Woodcock V</searchLink>; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kim+TW%22">Kim TW</searchLink>; Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Umana+P%22">Umana P</searchLink>; Pharma Research & Early Development, Roche Innovation Center Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22McIntyre+C%22">McIntyre C</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, UK.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Heichinger+C%22">Heichinger C</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hinton+H%22">Hinton H</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Saylan+T%22">Saylan T</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Davydov+II%22">Davydov II</searchLink>; Computational Sciences Center of Excellence, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guarin+E%22">Guarin E</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boehnke+A%22">Boehnke A</searchLink>; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland. axel.boehnke@roche.com.<br /><searchLink fieldCode="AU" term="%22Moreno+V%22">Moreno V</searchLink>; START Madrid-FJD, Hospital Fundación Jiménez Díaz, Madrid, Spain.
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