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Design and concise synthesis of halicyclamine-inspired bis-macrocycles targeting DedA membrane proteins.

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Title: Design and concise synthesis of halicyclamine-inspired bis-macrocycles targeting DedA membrane proteins.
Authors: Wayama T; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. hirokioguri@g.ecc.u-tokyo.ac.jp., Horinouchi R; School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan., Arai M; Graduate School and School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. araim@phs.osaka-u.ac.jp., Ohashi H; Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. watashi.k@jihs.go.jp., Watashi K; Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. watashi.k@jihs.go.jp., Yoshida S; Department of Applied Chemistry, School of Engineering, The University of Tokyo, FS CREATION, Mitsui LINK Lab, Kashiwanoha 1, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan., Sato S; Department of Applied Chemistry, School of Engineering, The University of Tokyo, FS CREATION, Mitsui LINK Lab, Kashiwanoha 1, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.; Institute for Molecular Science, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan., Tsukamoto S; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oehonmachi, Chuo-ku, Kumamoto 862-0973, Japan., Oguri H; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. hirokioguri@g.ecc.u-tokyo.ac.jp.
Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2026 May 07; Vol. 62 (35), pp. 9011-9015. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design and concise synthesis of halicyclamine-inspired bis-macrocycles targeting DedA membrane proteins.
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  Data: <searchLink fieldCode="AU" term="%22Wayama+T%22">Wayama T</searchLink>; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. hirokioguri@g.ecc.u-tokyo.ac.jp.<br /><searchLink fieldCode="AU" term="%22Horinouchi+R%22">Horinouchi R</searchLink>; School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Arai+M%22">Arai M</searchLink>; Graduate School and School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. araim@phs.osaka-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Ohashi+H%22">Ohashi H</searchLink>; Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. watashi.k@jihs.go.jp.<br /><searchLink fieldCode="AU" term="%22Watashi+K%22">Watashi K</searchLink>; Department of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. watashi.k@jihs.go.jp.<br /><searchLink fieldCode="AU" term="%22Yoshida+S%22">Yoshida S</searchLink>; Department of Applied Chemistry, School of Engineering, The University of Tokyo, FS CREATION, Mitsui LINK Lab, Kashiwanoha 1, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+S%22">Sato S</searchLink>; Department of Applied Chemistry, School of Engineering, The University of Tokyo, FS CREATION, Mitsui LINK Lab, Kashiwanoha 1, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.; Institute for Molecular Science, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.<br /><searchLink fieldCode="AU" term="%22Tsukamoto+S%22">Tsukamoto S</searchLink>; Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oehonmachi, Chuo-ku, Kumamoto 862-0973, Japan.<br /><searchLink fieldCode="AU" term="%22Oguri+H%22">Oguri H</searchLink>; Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. hirokioguri@g.ecc.u-tokyo.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%229610838%22">Chemical communications (Cambridge, England)</searchLink> [Chem Commun (Camb)] 2026 May 07; Vol. 62 (35), pp. 9011-9015. <i>Date of Electronic Publication: </i>2026 May 07.
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              Text: 2026 May 07
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