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A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models.

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Title: A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models.
Authors: Sawanobori Y; Department of Anesthesiology, Kagawa University, Kagawa, Japan.; Department of Pharmacology, Kagawa University, Kagawa, Japan., Nakano D; Department of Pharmacology, Kagawa University, Kagawa, Japan., Kitamura H; Department of Anesthesiology, Kagawa University, Kagawa, Japan., Kitada K; Department of Pharmacology, Kagawa University, Kagawa, Japan., Asaga T; Department of Anesthesiology, Kagawa University, Kagawa, Japan., Suzuki N; Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan., Yamamoto M; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Biochemistry and Molecular Biology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Ogino Y; Department of Anesthesiology, Kagawa University, Kagawa, Japan., Shirakami G; Department of Anesthesiology, Kagawa University, Kagawa, Japan., Nishiyama A; Department of Pharmacology, Kagawa University, Kagawa, Japan.
Source: PloS one [PLoS One] 2026 Apr 21; Vol. 21 (4), pp. e0343693. Date of Electronic Publication: 2026 Apr 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models.
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  Data: <searchLink fieldCode="AU" term="%22Sawanobori+Y%22">Sawanobori Y</searchLink>; Department of Anesthesiology, Kagawa University, Kagawa, Japan.; Department of Pharmacology, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Nakano+D%22">Nakano D</searchLink>; Department of Pharmacology, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kitamura+H%22">Kitamura H</searchLink>; Department of Anesthesiology, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kitada+K%22">Kitada K</searchLink>; Department of Pharmacology, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Asaga+T%22">Asaga T</searchLink>; Department of Anesthesiology, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+N%22">Suzuki N</searchLink>; Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+M%22">Yamamoto M</searchLink>; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Biochemistry and Molecular Biology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Ogino+Y%22">Ogino Y</searchLink>; Department of Anesthesiology, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Shirakami+G%22">Shirakami G</searchLink>; Department of Anesthesiology, Kagawa University, Kagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Nishiyama+A%22">Nishiyama A</searchLink>; Department of Pharmacology, Kagawa University, Kagawa, Japan.
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