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SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities.

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Title: SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities.
Authors: Pelzer B; Weill Cornell Medicine New York City United States., Meydan C; Weill Cornell Medicine New York, NY United States., Spiegel IM; Weill Cornell Medicine New York City, NY United States., Karagiannidis I; Weill Cornell Medicine New York, NY United States., Xia M; Weill Cornell Medicine New York, NY United States., Teater M; Weill Cornell Medicine New York, NY United States., Welter EM; University of Pennsylvania Philadelphia, PA United States., Searcy ZE; University of Pennsylvania Philadelphia, PA United States., Hilton LK; BC Cancer Agency Vancouver, BC Canada., Barisic D; Weill Cornell Medicine New York City, NY United States., Fong A; British Columbia Cancer Vancouver, British Columbia Canada., Fa P; Weill Cornell Medicine New York City, NY United States., Sethi S; Memorial Sloan Kettering Cancer Center New York City, NY United States., Isgor IS; Memorial Sloan Kettering Cancer Center New York City, NY United States., Fielding JJ; Dartmouth College Hanover, NH United States., Karbalayghareh A; Memorial Sloan Kettering Cancer Center New York City, NY United States., Burdette CS; Weill Cornell Medicine New York City, NY United States., Tumuluru S; Weill Cornell Medicine New York, NY United States., Debek SM; Weill Cornell Medicine New York City, NY United States., Lee S; Weill Cornell Medicine New York City, NY United States., Massoni-Badosa R; Weill Cornell Medicine New York City, NY United States., Durmaz C; Weill Cornell Medicine United States., Salataj E; Memorial Sloan Kettering Cancer Center New York, New York United States., Pararajalingam P; Memorial Sloan Kettering Cancer Center New York City, New York United States., Chen Z; Weill Cornell Medicine New York United States., Pelzl RJ; University of Erlangen-Nuremberg Erlangen, Bavaria Germany., Shah S; Weill Cornell Medicine New York City, NY United States., Rivas MA; University of Miami Miami, FL United States., Hoehn KB; Dartmouth College Hanover, NH United States., Mlynarczyk C; Yale University New Haven, CT United States., Isles HM; Weill Cornell Medicine New York City, NY United States., Wang X; Weill Cornell Medicine New York, NY United States., Dogan A; Memorial Sloan Kettering Cancer Center New York, NY United States., Elenitoba-Johnson KSJ; Memorial Sloan Kettering Cancer Center New York, NY United States., Scott DW; British Columbia Cancer Agency Vancouver Canada., Dreval K; BC Cancer Research Centre Vancouver Canada., Morin RD; Simon Fraser University Burnaby, British Columbia Canada., Leslie CS; Memorial Sloan Kettering Cancer Center New York, NY United States., Puri R; Cornell University Ithaca, NY United States., Geri JB; Weill Cornell Medicine United States., Chin CR; Weill Cornell Medicine New York, NY United States., Chadburn A; Weill Cornell Medicine New York, NY United States., Mason CE; Weill Cornell Medicine New York, NY United States., Reinhardt HC; University Hospital Essen Essen Germany., Anguera MC; University of Pennsylvania Philadelphia, PA United States., Béguelin W; Weill Cornell Medicine New York, New York United States., Venturutti L; University of British Columbia Vancouver, British Columbia Canada., Melnick AM; Weill Cornell Medicine New York, NY United States.
Source: Cancer discovery [Cancer Discov] 2026 Apr 21. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities.
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University of Pennsylvania Philadelphia, PA United States.<br /><searchLink fieldCode="AU" term="%22Hilton+LK%22">Hilton LK</searchLink>; BC Cancer Agency Vancouver, BC Canada.<br /><searchLink fieldCode="AU" term="%22Barisic+D%22">Barisic D</searchLink>; Weill Cornell Medicine New York City, NY United States.<br /><searchLink fieldCode="AU" term="%22Fong+A%22">Fong A</searchLink>; British Columbia Cancer Vancouver, British Columbia Canada.<br /><searchLink fieldCode="AU" term="%22Fa+P%22">Fa P</searchLink>; Weill Cornell Medicine New York City, NY United States.<br /><searchLink fieldCode="AU" term="%22Sethi+S%22">Sethi S</searchLink>; Memorial Sloan Kettering Cancer Center New York City, NY United States.<br /><searchLink fieldCode="AU" term="%22Isgor+IS%22">Isgor IS</searchLink>; Memorial Sloan Kettering Cancer Center New York City, NY United States.<br /><searchLink fieldCode="AU" term="%22Fielding+JJ%22">Fielding JJ</searchLink>; Dartmouth College Hanover, NH United States.<br /><searchLink fieldCode="AU" term="%22Karbalayghareh+A%22">Karbalayghareh A</searchLink>; 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Memorial Sloan Kettering Cancer Center New York City, New York United States.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Weill Cornell Medicine New York United States.<br /><searchLink fieldCode="AU" term="%22Pelzl+RJ%22">Pelzl RJ</searchLink>; University of Erlangen-Nuremberg Erlangen, Bavaria Germany.<br /><searchLink fieldCode="AU" term="%22Shah+S%22">Shah S</searchLink>; Weill Cornell Medicine New York City, NY United States.<br /><searchLink fieldCode="AU" term="%22Rivas+MA%22">Rivas MA</searchLink>; University of Miami Miami, FL United States.<br /><searchLink fieldCode="AU" term="%22Hoehn+KB%22">Hoehn KB</searchLink>; Dartmouth College Hanover, NH United States.<br /><searchLink fieldCode="AU" term="%22Mlynarczyk+C%22">Mlynarczyk C</searchLink>; Yale University New Haven, CT United States.<br /><searchLink fieldCode="AU" term="%22Isles+HM%22">Isles HM</searchLink>; Weill Cornell Medicine New York City, NY United States.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; 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Weill Cornell Medicine United States.<br /><searchLink fieldCode="AU" term="%22Chin+CR%22">Chin CR</searchLink>; Weill Cornell Medicine New York, NY United States.<br /><searchLink fieldCode="AU" term="%22Chadburn+A%22">Chadburn A</searchLink>; Weill Cornell Medicine New York, NY United States.<br /><searchLink fieldCode="AU" term="%22Mason+CE%22">Mason CE</searchLink>; Weill Cornell Medicine New York, NY United States.<br /><searchLink fieldCode="AU" term="%22Reinhardt+HC%22">Reinhardt HC</searchLink>; University Hospital Essen Essen Germany.<br /><searchLink fieldCode="AU" term="%22Anguera+MC%22">Anguera MC</searchLink>; University of Pennsylvania Philadelphia, PA United States.<br /><searchLink fieldCode="AU" term="%22Béguelin+W%22">Béguelin W</searchLink>; Weill Cornell Medicine New York, New York United States.<br /><searchLink fieldCode="AU" term="%22Venturutti+L%22">Venturutti L</searchLink>; University of British Columbia Vancouver, British Columbia Canada.<br /><searchLink fieldCode="AU" term="%22Melnick+AM%22">Melnick AM</searchLink>; Weill Cornell Medicine New York, NY United States.
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