GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.
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| Title: | GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy. |
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| Authors: | Timsina J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Jiang C; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Tao F; Human Genetics and Causal Biology, Eisai Center for Genetics-Guided Dementia Discovery, Eisai Inc, Cambridge, MA, USA., Dalmasso MC; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Estudios en Neurociencias y Sistemas Complejos (ENyS), CONICET-HEC-UNAJ, Buenos Aires, Argentina., Najar J; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Anastasi F; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Hospital del Mar Research Institute, Barcelona, Spain., Ohlei O; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany., Puerta Fuentes R; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Yang C; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Bradley J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Western D; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Ali M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Wang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Yang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Wu Y; Human Genetics and Causal Biology, Eisai Center for Genetics-Guided Dementia Discovery, Eisai Inc, Cambridge, MA, USA., Liu M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Budde J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Williams J; UK Dementia Research Institute at Cardiff, Cardiff, UK., Mahoney R; UK Dementia Research Institute at Cardiff, Cardiff, UK., Castillo Morales A; UK Dementia Research Institute at Cardiff, Cardiff, UK., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Dumitrescu L; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Wang TC; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Tesi N; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands., Kern S; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.; Department of Neuropsychiatry, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Waern M; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden., Skoog I; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.; Department of Neuropsychiatry, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., van Harten A; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Pijnenburg YAL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Sánchez-Juan P; Reina Sofia Alzheimer Center, CIEN Foundation, ISCIII, Madrid, Spain., Rodriguez-Rodriguez E; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital, Santander, Spain., Kleineidam L; Department of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Schneider A; Department of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Küçükali F; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Complex Genetics of Alzheimer's Disease Lab, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Bellenguez C; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ-U1167-RID-AGE Facteurs de Risque et Determiants moléculaires des maladies liées au vieillissement, Lille, France., Grenier-Boley B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ-U1167-RID-AGE Facteurs de Risque et Determiants moléculaires des maladies liées au vieillissement, Lille, France., Heikkinen S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., de Rojas I; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Rujescu D; Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany., Scherbaum N; LVR-University Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Hausner L; Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Grimmer T; Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Medical Science Department, iBiMED, Aveiro, Portugal., Vandenberghe R; Department of Neurology, UZ Leuven, Leuven, Belgium., Engelborghs S; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Universitair Ziekenhuis Brussel and Neuroprotection and Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Tegos T; 1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki, Greece., Scarmeas N; 1st Department of Neurology, Aiginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Depatment of Neurology, Columbia University, New York, NY, USA., Dols-Icardo O; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Sant Pau Memory Unit, Institut de Recerca Sant Pau, Department of Neurology, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Moreno F; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, San Sebastian, Spain.; Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain., Pérez-Tur J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain., Bullido MJ; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Universidad Autónoma de Madrid, Madrid, Spain., Sánchez-Valle R; Alzheimer's disease and other cognitive disorders unit. Service of Neurology. Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Álvarez V; Laboratorio de Genética. Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. del Hospital Universitario, Asturias, Spain., García-González P; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Mir P; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga, Málaga, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., García-Alberca JM; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain.; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., Seelaar H; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Ramakers I; Maastricht University, Department of Psychiatry & Neuropsychologie, Alzheimer Center Limburg, Maastricht, the Netherlands., Papma J; Neurology department Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Internal Medicine Department, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Hulsman M; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar Technical University Munich, Munich, Germany., Perneczky R; German Center for Neurodegenerative Diseases (DZNE Munich), Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK., Buerger K; German Center for Neurodegenerative Diseases (DZNE Munich), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Nöthen MM; Institute of Human Genetics; University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Lewczuk P; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.; Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland., Kornhuber J; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany., Hampel H; Sorbonne University, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, Paris, France., Giegling I; Division of General Psychiatry, Dept. of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Goldhardt O; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany., Diehl-Schmid J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany., Andrade V; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany., Heneka MM; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Frölich L; Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Vogelgsang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; Department of Psychiatry, Harvard Medical School McLean Hospital, Belmont, MA, USA., Graff C; Division of Neurogeriatrics, Department NVS, Karolinska Institutet, Center for Alzheimer Research, Stockholm, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden., Thonberg H; Division of Neurogeriatrics, Department NVS, Karolinska Institutet, Center for Alzheimer Research, Stockholm, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden., Ullgren A; Division of Neurogeriatrics, Department NVS, Karolinska Institutet, Center for Alzheimer Research, Stockholm, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden., Papenberg G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Deleuze JF; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., Dufouil C; Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Univ Bordeaux, Bordeaux, France.; CHU de Bordeaux, Pole santé publique, Bordeaux, France., Wagner M; Department of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany., Holstege H; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium., van Duijn C; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Centre for Artificial Intelligence in Precision Medicine, University of Oxford, Oxford, UK., Lebouvier T; Univ.Lille, Inserm, CHULille, Lille Neuroscience & Cognition, UMR-S1172, Lille, France., Hannon O; Université de Paris, EA 4468, APHP, Hôpital Broca, Paris, France., Leinonen V; Department of Neurosurgery, Kuopio University Hospital and Institute of Clinical Medicine-Neurosurgery, University of Eastern Finland, Kuopio, Finland., Soininen H; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Herukka SK; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, NeuroCenter, Kuopio University Hospital, Kuopio, Finland., Giedraitis V; Department of Public Health and Caring Sciences/Clinical Geriatrics, Uppsala University, Uppsala, Sweden., Löwenmark M; Department of Public Health and Caring Sciences/Clinical Geriatrics, Uppsala University, Uppsala, Sweden., Kilander L; Department of Public Health and Caring Sciences/Clinical Geriatrics, Uppsala University, Uppsala, Sweden., Genius P; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Hospital del Mar Research Institute, Barcelona, Spain., Rodríguez B; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Hospital del Mar Research Institute, Barcelona, Spain., Luckett ES; Department of Radiology and Nuclear Medicine, Amsterdam UMC location VUmc, Amsterdam, Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, The Netherlands.; Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium.; Laboratory for Complex Genetics, KU Leuven, Leuven, Belgium., Navarro A; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.; Department of Experimental and Health Sciences, Institute of Evolutionary Biology (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain., Cano A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Blennow K; Clinical neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France., Zetterberg H; Clinical neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Lleo A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Sant Pau Memory Unit, Institut de Recerca Sant Pau, Department of Neurology, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Boada M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Ruiz A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases and Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA., Lee VM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Van Deerlin VM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Deming Y; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Johnson SC; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Engelman CD; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Pastor P; Unit of Neurodegenerative diseases, Department of Neurology, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain., Alvarez I; Unit of Neurodegenerative diseases, Department of Neurology, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain., Peskind ER; Veterans Affairs Northwest Mental Illness Research, Education, and Clinical Center, Seattle, WA, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA., Heslegrave AJ; UK Dementia Research Institute at UCL, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Saykin AJ; Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA., Nho K; Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA., Schindler SE; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., McDade E; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Renton AE; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goate A; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ibanez L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA., Riemenschneider M; Department of Psychiatry, Saarland University, Homburg, Germany., Albert MS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Laws SM; Centre for Precision Health, School of Medical Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Porter T; Centre for Precision Health, School of Medical Health Sciences, Edith Cowan University, Joondalup, WA, Australia., O'Brien EK; Centre for Precision Health, School of Medical Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Shaw LM; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases and Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA., Tijms BM; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Ingelsson M; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Visser PJ; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VUmc, Amsterdam, the Netherlands.; Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.; Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Sleegers K; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Complex Genetics of Alzheimer's Disease Lab, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Ritchie CW; Scottish Brain Sciences, Scottish Gas Murrayfield Stadium, Edinburgh, UK.; School of Medicine, University of St Andrews, St Andrews, UK., Sims R; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Belloy M; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ-U1167-RID-AGE Facteurs de Risque et Determiants moléculaires des maladies liées au vieillissement, Lille, France., Vilor-Tejedor N; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Hospital del Mar Research Institute, Barcelona, Spain.; Department of Human Genetics, Radboud University Medical Center, Nijgmegen, the Netherlands., Fernández MV; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Li QS; Neuroscience, Janssen Research & Development LLC, Titusville, NJ, USA.; JRD Data Science, Janssen Research & Development LLC, Titusville, NJ, USA.; CHDI Management Inc., Princeton, NJ, USA., Nagle MW; Human Genetics and Causal Biology, Eisai Center for Genetics-Guided Dementia Discovery, Eisai Inc, Cambridge, MA, USA., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Disease (CECAD), University of Cologne, Cologne, Germany., Bertram L; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., van der Lee SJ; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu. |
| Source: | Nature communications [Nat Commun] 2026 Apr 21. Date of Electronic Publication: 2026 Apr 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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