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Inhibition of calpain-mediated HMGB1 alleviates cardiac inflammation and dysfunction induced by ultra-processed foods.

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Title: Inhibition of calpain-mediated HMGB1 alleviates cardiac inflammation and dysfunction induced by ultra-processed foods.
Authors: Ross C; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Gare SR; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Alatawi NH; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Fonseka O; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Chen X; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Zhang J; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Han Y; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Ruiz-Velasco A; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Abouleisa RR; Surgery Department, Baylor College of Medicine, Houston, Texas, USA., Liu Y; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Zhao X; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Xiao H; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China., Keavney BD; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Manchester Heart Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom., Howell GJ; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Wang T; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Mohamed TM; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Surgery Department, Baylor College of Medicine, Houston, Texas, USA., Cartwright EJ; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Liu W; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Source: JCI insight [JCI Insight] 2026 Apr 09; Vol. 11 (11). Date of Electronic Publication: 2026 Apr 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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              Text: 2026 Apr 09
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