Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE.
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| Title: | Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE. |
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| Authors: | Mwizerwa O; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Pediatrics & Rheumatology, Dr. Georges‑L.‑Dumont University Hospital Centre, Moncton, New Brunswick, Canada., Ledochowski J; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada., Ramanathan G; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada., Tal TE; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Division of Rheumatology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada., Mossad SI; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada., Zapparoli B; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada., Ng L; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada., Jeyanathan A; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada., Davis A; Department of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada., Hiraki LT; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada., Levy DM; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada., Wither J; University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada.; Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Rheumatology, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Touma Z; University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada.; Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Rheumatology, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada., Danguecan A; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada., Yeh A; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada., Knight AM; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada andrea.knight@sickkids.ca.; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada. |
| Source: | Lupus science & medicine [Lupus Sci Med] 2026 Apr 22; Vol. 13 (1). Date of Electronic Publication: 2026 Apr 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BMJ Country of Publication: England NLM ID: 101633705 Publication Model: Electronic Cited Medium: Print ISSN: 2053-8790 (Print) Linking ISSN: 20538790 NLM ISO Abbreviation: Lupus Sci Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42020152 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Mwizerwa+O%22">Mwizerwa O</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Pediatrics & Rheumatology, Dr. Georges‑L.‑Dumont University Hospital Centre, Moncton, New Brunswick, Canada.<br /><searchLink fieldCode="AU" term="%22Ledochowski+J%22">Ledochowski J</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ramanathan+G%22">Ramanathan G</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tal+TE%22">Tal TE</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Division of Rheumatology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mossad+SI%22">Mossad SI</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zapparoli+B%22">Zapparoli B</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ng+L%22">Ng L</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Jeyanathan+A%22">Jeyanathan A</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Davis+A%22">Davis A</searchLink>; Department of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hiraki+LT%22">Hiraki LT</searchLink>; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Levy+DM%22">Levy DM</searchLink>; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wither+J%22">Wither J</searchLink>; University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada.; Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Rheumatology, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Touma+Z%22">Touma Z</searchLink>; University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada.; Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Rheumatology, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Danguecan+A%22">Danguecan A</searchLink>; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yeh+A%22">Yeh A</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Knight+AM%22">Knight AM</searchLink>; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada andrea.knight@sickkids.ca.; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.; Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101633705%22">Lupus science & medicine</searchLink> [Lupus Sci Med] 2026 Apr 22; Vol. 13 (1). <i>Date of Electronic Publication: </i>2026 Apr 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ%22">BMJ </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101633705 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2053-8790 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220538790%22">20538790 </searchLink><i>NLM ISO Abbreviation: </i>Lupus Sci Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42020152 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1136/lupus-2025-001922 Languages: – Code: eng Text: English Titles: – TitleFull: Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mwizerwa O – PersonEntity: Name: NameFull: Ledochowski J – PersonEntity: Name: NameFull: Ramanathan G – PersonEntity: Name: NameFull: Tal TE – PersonEntity: Name: NameFull: Mossad SI – PersonEntity: Name: NameFull: Zapparoli B – PersonEntity: Name: NameFull: Ng L – PersonEntity: Name: NameFull: Jeyanathan A – PersonEntity: Name: NameFull: Davis A – PersonEntity: Name: NameFull: Hiraki LT – PersonEntity: Name: NameFull: Levy DM – PersonEntity: Name: NameFull: Wither J – PersonEntity: Name: NameFull: Touma Z – PersonEntity: Name: NameFull: Danguecan A – PersonEntity: Name: NameFull: Yeh A – PersonEntity: Name: NameFull: Knight AM IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 04 Text: 2026 Apr 22 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2053-8790 Numbering: – Type: volume Value: 13 – Type: issue Value: 1 Titles: – TitleFull: Lupus science & medicine Type: main |
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