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TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

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Title: TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.
Authors: Walth-Hummel AA; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Jouffe C; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Weber P; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Motzler K; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Geppert J; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Sterr M; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany., Gan W; Human Genetics Centre of Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Szczerbinska I; Department of Discovery Biology and Pharmacology, Novo Nordisk Research Centre Oxford, Oxford, UK., König AC; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany., Hauck SM; DZD (German Center for Diabetes Research), Munich, Germany.; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany., Terron-Exposito R; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Hass D; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Wang C; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.; School of Medicine and Health, Technical University of Munich, Munich, Germany., Dyar KA; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Lyon JG; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada., Lickert H; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; School of Medicine and Health, Technical University of Munich, Munich, Germany., Ämmälä C; Department of Discovery Biology and Pharmacology, Novo Nordisk Research Centre Oxford, Oxford, UK., Herzig S; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.; Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany., Ashcroft FM; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Bakhti M; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany., MacDonald PE; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada., Rohm M; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany. maria.rohm@helmholtz-munich.de.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany. maria.rohm@helmholtz-munich.de.; DZD (German Center for Diabetes Research), Munich, Germany. maria.rohm@helmholtz-munich.de.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. maria.rohm@helmholtz-munich.de.
Source: Nature communications [Nat Commun] 2026 Apr 23; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.
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  Data: <searchLink fieldCode="AU" term="%22Walth-Hummel+AA%22">Walth-Hummel AA</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jouffe+C%22">Jouffe C</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+P%22">Weber P</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Motzler+K%22">Motzler K</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Geppert+J%22">Geppert J</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sterr+M%22">Sterr M</searchLink>; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gan+W%22">Gan W</searchLink>; Human Genetics Centre of Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Szczerbinska+I%22">Szczerbinska I</searchLink>; Department of Discovery Biology and Pharmacology, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22König+AC%22">König AC</searchLink>; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hauck+SM%22">Hauck SM</searchLink>; DZD (German Center for Diabetes Research), Munich, Germany.; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Terron-Exposito+R%22">Terron-Exposito R</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hass+D%22">Hass D</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.; School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dyar+KA%22">Dyar KA</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lyon+JG%22">Lyon JG</searchLink>; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Lickert+H%22">Lickert H</searchLink>; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ämmälä+C%22">Ämmälä C</searchLink>; Department of Discovery Biology and Pharmacology, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Herzig+S%22">Herzig S</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.; Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ashcroft+FM%22">Ashcroft FM</searchLink>; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bakhti+M%22">Bakhti M</searchLink>; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22MacDonald+PE%22">MacDonald PE</searchLink>; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Rohm+M%22">Rohm M</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany. maria.rohm@helmholtz-munich.de.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany. maria.rohm@helmholtz-munich.de.; DZD (German Center for Diabetes Research), Munich, Germany. maria.rohm@helmholtz-munich.de.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. maria.rohm@helmholtz-munich.de.
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