TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.
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| Title: | TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network. |
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| Authors: | Walth-Hummel AA; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Jouffe C; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Weber P; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Motzler K; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Geppert J; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Sterr M; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany., Gan W; Human Genetics Centre of Excellence, Novo Nordisk Research Centre Oxford, Oxford, UK., Szczerbinska I; Department of Discovery Biology and Pharmacology, Novo Nordisk Research Centre Oxford, Oxford, UK., König AC; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany., Hauck SM; DZD (German Center for Diabetes Research), Munich, Germany.; Metabolomics and Proteomics Core (MPC), Helmholtz Center Munich, Neuherberg, Germany., Terron-Exposito R; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Hass D; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany., Wang C; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.; School of Medicine and Health, Technical University of Munich, Munich, Germany., Dyar KA; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany., Lyon JG; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada., Lickert H; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; School of Medicine and Health, Technical University of Munich, Munich, Germany., Ämmälä C; Department of Discovery Biology and Pharmacology, Novo Nordisk Research Centre Oxford, Oxford, UK., Herzig S; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany.; DZD (German Center for Diabetes Research), Munich, Germany.; Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany., Ashcroft FM; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Bakhti M; DZD (German Center for Diabetes Research), Munich, Germany.; Institute of Diabetes and Regeneration Research (IDR), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany., MacDonald PE; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Canada., Rohm M; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany. maria.rohm@helmholtz-munich.de.; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, University Hospital, Heidelberg, Germany. maria.rohm@helmholtz-munich.de.; DZD (German Center for Diabetes Research), Munich, Germany. maria.rohm@helmholtz-munich.de.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. maria.rohm@helmholtz-munich.de. |
| Source: | Nature communications [Nat Commun] 2026 Apr 23; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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