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CDKN1B inactivation impacts ER signaling and drives resistance to endocrine therapy in breast cancer.

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Title: CDKN1B inactivation impacts ER signaling and drives resistance to endocrine therapy in breast cancer.
Authors: Ahmad S; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.; Homi Bhabha National Institute, Training School Complex, Mumbai, India., Butle A; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, India., Karn A; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India., Sunder R; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India., Mishra R; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India., Bawaskar B; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India., Parab P; Clinical Genomics and Hypoxia Lab (Clinician Scientist Lab), TMC-ACTREC, Navi Mumbai, India.; Departments of Surgical Oncology and Medical Oncology, Tata Memorial Hospital, Mumbai, India., Raje V; Department of Surgical Pathology, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India., Chaubal R; Clinical Genomics and Hypoxia Lab (Clinician Scientist Lab), TMC-ACTREC, Navi Mumbai, India.; Departments of Surgical Oncology and Medical Oncology, Tata Memorial Hospital, Mumbai, India., Shet T; Department of Pathology, Tata Memorial Hospital, Mumbai, India., Kundu G; School of Biotechnology, KIIT Deemed to Be University, Bhubaneswar, India., Gupta S; Homi Bhabha National Institute, Training School Complex, Mumbai, India. sudeep.gupta@actrec.gov.in.; Clinical Genomics and Hypoxia Lab (Clinician Scientist Lab), TMC-ACTREC, Navi Mumbai, India. sudeep.gupta@actrec.gov.in.; Departments of Surgical Oncology and Medical Oncology, Tata Memorial Hospital, Mumbai, India. sudeep.gupta@actrec.gov.in., Dutt A; Integrated Cancer Genomics Laboratory, Department of Genetics, University of Delhi South Campus, New Delhi, India. amitdutt@south.du.ac.in.
Source: British journal of cancer [Br J Cancer] 2026 Jul; Vol. 135 (2), pp. 303-315. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ahmad+S%22">Ahmad S</searchLink>; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.; Homi Bhabha National Institute, Training School Complex, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Butle+A%22">Butle A</searchLink>; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, India.<br /><searchLink fieldCode="AU" term="%22Karn+A%22">Karn A</searchLink>; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Sunder+R%22">Sunder R</searchLink>; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Mishra+R%22">Mishra R</searchLink>; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Bawaskar+B%22">Bawaskar B</searchLink>; Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Parab+P%22">Parab P</searchLink>; Clinical Genomics and Hypoxia Lab (Clinician Scientist Lab), TMC-ACTREC, Navi Mumbai, India.; Departments of Surgical Oncology and Medical Oncology, Tata Memorial Hospital, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Raje+V%22">Raje V</searchLink>; Department of Surgical Pathology, Advanced Centre for Treatment, Research, and Education in Cancer, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Chaubal+R%22">Chaubal R</searchLink>; Clinical Genomics and Hypoxia Lab (Clinician Scientist Lab), TMC-ACTREC, Navi Mumbai, India.; Departments of Surgical Oncology and Medical Oncology, Tata Memorial Hospital, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Shet+T%22">Shet T</searchLink>; Department of Pathology, Tata Memorial Hospital, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Kundu+G%22">Kundu G</searchLink>; School of Biotechnology, KIIT Deemed to Be University, Bhubaneswar, India.<br /><searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Homi Bhabha National Institute, Training School Complex, Mumbai, India. sudeep.gupta@actrec.gov.in.; Clinical Genomics and Hypoxia Lab (Clinician Scientist Lab), TMC-ACTREC, Navi Mumbai, India. sudeep.gupta@actrec.gov.in.; Departments of Surgical Oncology and Medical Oncology, Tata Memorial Hospital, Mumbai, India. sudeep.gupta@actrec.gov.in.<br /><searchLink fieldCode="AU" term="%22Dutt+A%22">Dutt A</searchLink>; Integrated Cancer Genomics Laboratory, Department of Genetics, University of Delhi South Campus, New Delhi, India. amitdutt@south.du.ac.in.
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              Text: 2026 Jul
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