Systematic Disruption of Zebrafish Fibrillin Genes Identifies a Translational Zebrafish Model for Marfan Syndrome.

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Title: Systematic Disruption of Zebrafish Fibrillin Genes Identifies a Translational Zebrafish Model for Marfan Syndrome.
Authors: De Rycke K; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Horvat M; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Caboor L; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Vermassen P; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., De Smet G; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Lobbestael S; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Santana Silva M; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Steyaert W; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Van Impe M; Biophysical Models for Medical Applications (BioMMedA), Institute of Biomedical Engineering and Technology (IBiTech), Ghent University, Ghent, Belgium., Segers P; Biophysical Models for Medical Applications (BioMMedA), Institute of Biomedical Engineering and Technology (IBiTech), Ghent University, Ghent, Belgium., De Backer J; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Department of Cardiology, Ghent University Hospital, Ghent, Belgium., Sips P; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium. Electronic address: patrick.sips@ugent.be.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2026 May; Vol. 11 (5), pp. 101543. Date of Electronic Publication: 2026 Apr 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Systematic Disruption of Zebrafish Fibrillin Genes Identifies a Translational Zebrafish Model for Marfan Syndrome.
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  Data: <searchLink fieldCode="AU" term="%22De+Rycke+K%22">De Rycke K</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Horvat+M%22">Horvat M</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Caboor+L%22">Caboor L</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Vermassen+P%22">Vermassen P</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Smet+G%22">De Smet G</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Lobbestael+S%22">Lobbestael S</searchLink>; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Santana+Silva+M%22">Santana Silva M</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Steyaert+W%22">Steyaert W</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Impe+M%22">Van Impe M</searchLink>; Biophysical Models for Medical Applications (BioMMedA), Institute of Biomedical Engineering and Technology (IBiTech), Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Segers+P%22">Segers P</searchLink>; Biophysical Models for Medical Applications (BioMMedA), Institute of Biomedical Engineering and Technology (IBiTech), Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Backer+J%22">De Backer J</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Department of Cardiology, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Sips+P%22">Sips P</searchLink>; Center for Medical Genetics Ghent (CMGG), Department of Biomolecular Medicine, Ghent University, Ghent, Belgium. Electronic address: patrick.sips@ugent.be.
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  Data: <searchLink fieldCode="JN" term="%22101677259%22">JACC. Basic to translational science</searchLink> [JACC Basic Transl Sci] 2026 May; Vol. 11 (5), pp. 101543. <i>Date of Electronic Publication: </i>2026 Apr 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+on+behalf+of+the+American+College+of+Cardiology+Foundation%22">Elsevier on behalf of the American College of Cardiology Foundation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101677259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2452-302X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222452302X%22">2452302X </searchLink><i>NLM ISO Abbreviation: </i>JACC Basic Transl Sci <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 May
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