Impact of pre-existing interstitial lung abnormalities on pneumonitis risk and survival in chemo-naive patients with non-small-cell lung cancer receiving pembrolizumab plus chemotherapy.
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| Title: | Impact of pre-existing interstitial lung abnormalities on pneumonitis risk and survival in chemo-naive patients with non-small-cell lung cancer receiving pembrolizumab plus chemotherapy. |
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| Authors: | Machiyama H; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Immunogenomic Medicine, Research Institute, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan., Matsumoto K; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan., Shiroyama T; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan. Electronic address: takayuki.s12@hotmail.co.jp., Miyazaki A; Department of Respiratory Medicine, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 540-8567, Japan., Komuta K; Department of Respiratory Medicine, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 540-8567, Japan., Tamiya M; Department of Respiratory Medicine, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 540-8567, Japan., Tsukaguchi A; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Internal Medicine, NHO Kinki Chuo Chest Medical Center, 1180, Nagasone-cho Kita-ku, Sakai, Osaka, 591-8555, Japan., Tamiya A; Department of Internal Medicine, NHO Kinki Chuo Chest Medical Center, 1180, Nagasone-cho Kita-ku, Sakai, Osaka, 591-8555, Japan., Kinehara Y; Department of Respiratory Medicine and Clinical Immunology, Nippon Life Hospital, 2-1-54 Enokojima, Nishi-ku, Osaka, 550-0006, Japan., Moritomo K; Department of Respiratory Medicine, Osaka Keisatsu Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka, 543-8555, Japan., Shoshihara N; Department of Respiratory Medicine, Osaka Keisatsu Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka, 543-8555, Japan., Kuge T; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Thoracic Oncology, NHO Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka City, Osaka, 560-8552, Japan., Mihashi Y; Department of Thoracic Oncology, NHO Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka City, Osaka, 560-8552, Japan., Mori M; Department of Thoracic Oncology, NHO Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka City, Osaka, 560-8552, Japan., Yamauchi K; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Thoracic Oncology, Osaka Habikino Medical Center, 3-7-1 Habikino, Habikino-shi, Osaka, 583-8588, Japan., Suzuki H; Department of Thoracic Oncology, Osaka Habikino Medical Center, 3-7-1 Habikino, Habikino-shi, Osaka, 583-8588, Japan., Kato S; Department of Respiratory Medicine, Ikeda City Hospital, 3-1-18 Jonan, Ikeda City, Osaka, 563-8510, Japan., Nishikawa Y; Department of Respiratory Medicine, Toyonaka Municipal Hospital, 4-14-1 Shibahara-cho, Toyonaka-shi, Osaka, 560-8565, Japan., Niki T; Department of Respiratory Medicine, Nishinomiya Municipal Central Hospital, 8-24 Hayashida-cho, Nishinomiya City, Hyogo, 663-8014, Japan., Azuma K; Department of Respiratory Medicine, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan., Osa A; Department of Respiratory Medicine, Kinki Central Hospital, 3-1 Kurumazuka, Itami City, Hyogo, 664-8533, Japan., Takeda Y; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan., Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Immunopathology, World Premier International (WPI), Immunology Frontier Research Center (iFReC), The University of Osaka, 3-1 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Center for Infectious Diseases for Education and Research (CiDER), The University of Osaka, 1-10 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Japan Agency for Medical Research and Development - Core Research for Evolutional Science and Technology (AMED-CREST), The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Center for Advanced Modalities and DDS (CAMaD), The University of Osaka, 1-10 Yamadaoka, Suita City, Osaka, 565-0871, Japan. |
| Source: | Respiratory medicine [Respir Med] 2026 Jun; Vol. 257, pp. 108852. Date of Electronic Publication: 2026 Apr 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42025817 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Impact of pre-existing interstitial lung abnormalities on pneumonitis risk and survival in chemo-naive patients with non-small-cell lung cancer receiving pembrolizumab plus chemotherapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Machiyama+H%22">Machiyama H</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Immunogenomic Medicine, Research Institute, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+K%22">Matsumoto K</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Shiroyama+T%22">Shiroyama T</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan. Electronic address: takayuki.s12@hotmail.co.jp.<br /><searchLink fieldCode="AU" term="%22Miyazaki+A%22">Miyazaki A</searchLink>; Department of Respiratory Medicine, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 540-8567, Japan.<br /><searchLink fieldCode="AU" term="%22Komuta+K%22">Komuta K</searchLink>; Department of Respiratory Medicine, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 540-8567, Japan.<br /><searchLink fieldCode="AU" term="%22Tamiya+M%22">Tamiya M</searchLink>; Department of Respiratory Medicine, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 540-8567, Japan.<br /><searchLink fieldCode="AU" term="%22Tsukaguchi+A%22">Tsukaguchi A</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Internal Medicine, NHO Kinki Chuo Chest Medical Center, 1180, Nagasone-cho Kita-ku, Sakai, Osaka, 591-8555, Japan.<br /><searchLink fieldCode="AU" term="%22Tamiya+A%22">Tamiya A</searchLink>; Department of Internal Medicine, NHO Kinki Chuo Chest Medical Center, 1180, Nagasone-cho Kita-ku, Sakai, Osaka, 591-8555, Japan.<br /><searchLink fieldCode="AU" term="%22Kinehara+Y%22">Kinehara Y</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Nippon Life Hospital, 2-1-54 Enokojima, Nishi-ku, Osaka, 550-0006, Japan.<br /><searchLink fieldCode="AU" term="%22Moritomo+K%22">Moritomo K</searchLink>; Department of Respiratory Medicine, Osaka Keisatsu Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka, 543-8555, Japan.<br /><searchLink fieldCode="AU" term="%22Shoshihara+N%22">Shoshihara N</searchLink>; Department of Respiratory Medicine, Osaka Keisatsu Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka, 543-8555, Japan.<br /><searchLink fieldCode="AU" term="%22Kuge+T%22">Kuge T</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Thoracic Oncology, NHO Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka City, Osaka, 560-8552, Japan.<br /><searchLink fieldCode="AU" term="%22Mihashi+Y%22">Mihashi Y</searchLink>; Department of Thoracic Oncology, NHO Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka City, Osaka, 560-8552, Japan.<br /><searchLink fieldCode="AU" term="%22Mori+M%22">Mori M</searchLink>; Department of Thoracic Oncology, NHO Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka City, Osaka, 560-8552, Japan.<br /><searchLink fieldCode="AU" term="%22Yamauchi+K%22">Yamauchi K</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Thoracic Oncology, Osaka Habikino Medical Center, 3-7-1 Habikino, Habikino-shi, Osaka, 583-8588, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+H%22">Suzuki H</searchLink>; Department of Thoracic Oncology, Osaka Habikino Medical Center, 3-7-1 Habikino, Habikino-shi, Osaka, 583-8588, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+S%22">Kato S</searchLink>; Department of Respiratory Medicine, Ikeda City Hospital, 3-1-18 Jonan, Ikeda City, Osaka, 563-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Nishikawa+Y%22">Nishikawa Y</searchLink>; Department of Respiratory Medicine, Toyonaka Municipal Hospital, 4-14-1 Shibahara-cho, Toyonaka-shi, Osaka, 560-8565, Japan.<br /><searchLink fieldCode="AU" term="%22Niki+T%22">Niki T</searchLink>; Department of Respiratory Medicine, Nishinomiya Municipal Central Hospital, 8-24 Hayashida-cho, Nishinomiya City, Hyogo, 663-8014, Japan.<br /><searchLink fieldCode="AU" term="%22Azuma+K%22">Azuma K</searchLink>; Department of Respiratory Medicine, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan.<br /><searchLink fieldCode="AU" term="%22Osa+A%22">Osa A</searchLink>; Department of Respiratory Medicine, Kinki Central Hospital, 3-1 Kurumazuka, Itami City, Hyogo, 664-8533, Japan.<br /><searchLink fieldCode="AU" term="%22Takeda+Y%22">Takeda Y</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Kumanogoh+A%22">Kumanogoh A</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Department of Immunopathology, World Premier International (WPI), Immunology Frontier Research Center (iFReC), The University of Osaka, 3-1 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Center for Infectious Diseases for Education and Research (CiDER), The University of Osaka, 1-10 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Japan Agency for Medical Research and Development - Core Research for Evolutional Science and Technology (AMED-CREST), The University of Osaka, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan; Center for Advanced Modalities and DDS (CAMaD), The University of Osaka, 1-10 Yamadaoka, Suita City, Osaka, 565-0871, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228908438%22">Respiratory medicine</searchLink> [Respir Med] 2026 Jun; Vol. 257, pp. 108852. <i>Date of Electronic Publication: </i>2026 Apr 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8908438 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-3064 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209546111%22">09546111 </searchLink><i>NLM ISO Abbreviation: </i>Respir Med <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.rmed.2026.108852 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 108852 Titles: – TitleFull: Impact of pre-existing interstitial lung abnormalities on pneumonitis risk and survival in chemo-naive patients with non-small-cell lung cancer receiving pembrolizumab plus chemotherapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Machiyama H – PersonEntity: Name: NameFull: Matsumoto K – PersonEntity: Name: NameFull: Shiroyama T – PersonEntity: Name: NameFull: Miyazaki A – PersonEntity: Name: NameFull: Komuta K – PersonEntity: Name: NameFull: Tamiya M – PersonEntity: Name: NameFull: Tsukaguchi A – PersonEntity: Name: NameFull: Tamiya A – PersonEntity: Name: NameFull: Kinehara Y – PersonEntity: Name: NameFull: Moritomo K – PersonEntity: Name: NameFull: Shoshihara N – PersonEntity: Name: NameFull: Kuge T – PersonEntity: Name: NameFull: Mihashi Y – PersonEntity: Name: NameFull: Mori M – PersonEntity: Name: NameFull: Yamauchi K – PersonEntity: Name: NameFull: Suzuki H – PersonEntity: Name: NameFull: Kato S – PersonEntity: Name: NameFull: Nishikawa Y – PersonEntity: Name: NameFull: Niki T – PersonEntity: Name: NameFull: Azuma K – PersonEntity: Name: NameFull: Osa A – PersonEntity: Name: NameFull: Takeda Y – PersonEntity: Name: NameFull: Kumanogoh A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1532-3064 Numbering: – Type: volume Value: 257 Titles: – TitleFull: Respiratory medicine Type: main |
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