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Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study).

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Title: Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study).
Authors: Serra-Aracil X; Department of Surgery, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain. javier.serra@uab.cat., Nonell A; Department of Surgery, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain., Gener-Jorge C; Department of Pathology, Universitat Autònoma de Barcelona, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain., Pericay C; Medical Oncology Department, Mutua de Terrassa University Hospital, Terrassa (Barcelona), Spain., Golda T; Colorectal Unit, General and Digestive Surgery Department, Bellvitge University Hospital, Barcelona, Spain., Kreisler E; Colorectal Unit, General and Digestive Surgery Department, Bellvitge University Hospital, Barcelona, Spain., Espin-Basany E; Colorectal Unit, General and Digestive Surgery Department, Vall d'Hebron University Hospital, Departamento de Cirugía, Universitat Autònoma de Barcelona, Barcelona, Spain., Pallisera A; Department of Surgery, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain., Badia-Closa J; Colorectal Unit, General and Digestive Surgery Department, Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain., Espina B; Colorectal Unit, General and Digestive Surgery Department, Santa Creu I Sant Pau University Hospital, Barcelona, Spain., Borda-Arrizabalaga N; General and Digestive Surgery Department, Donostia University Hospital, Donostia, Gipuzkoa, Spain., Reina A; Colorectal Unit, Unidad de Gestión Clínica Cirugía y Area de Gestión Norte de Almería, Complejo Hospitalario Torrecárdenas, Almería, Spain., Guadalajara-Labajo H; Colorectal Unit, General and Digestive Surgery Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Otero A; General and Digestive Surgery Department, Hospital Clinic University Hospital, Barcelona, Spain., Delgado S; Colorectal Unit, General and Digestive Surgery Department, Mutua de Terrassa University Hospital, Terrassa (Barcelona), Spain., Kraft M; Colorectal Unit, General and Digestive Surgery Department, Vall d'Hebron University Hospital, Departamento de Cirugía, Universitat Autònoma de Barcelona, Barcelona, Spain., Querol R; Department of Medical Oncology, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell, Spain., Flor B; Colorectal Unit, General and Digestive Surgery Department, La Fe University Hospital, Valencia, Spain., Pellino G; Colorectal Unit, General and Digestive Surgery Department, Vall d'Hebron University Hospital, Departamento de Cirugía, Universitat Autònoma de Barcelona, Barcelona, Spain., Biondo S; Colorectal Unit, General and Digestive Surgery Department, Bellvitge University Hospital, Barcelona, Spain., Caro-Tarrago A; Colorectal Unit, General and Digestive Surgery Department, Joan XXIII University Hospital, Tarragona, Spain.
Corporate Authors: TAUTEM-T1 collaborative group
Source: International journal of colorectal disease [Int J Colorectal Dis] 2026 Apr 23; Vol. 41 (1). Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Clinical Trial, Phase III; Multicenter Study; Randomized Controlled Trial; Equivalence Trial; Comparative Study
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 8607899 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1262 (Electronic) Linking ISSN: 01791958 NLM ISO Abbreviation: Int J Colorectal Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study).
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  Data: <searchLink fieldCode="AU" term="%22Serra-Aracil+X%22">Serra-Aracil X</searchLink>; Department of Surgery, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain. javier.serra@uab.cat.<br /><searchLink fieldCode="AU" term="%22Nonell+A%22">Nonell A</searchLink>; Department of Surgery, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain.<br /><searchLink fieldCode="AU" term="%22Gener-Jorge+C%22">Gener-Jorge C</searchLink>; Department of Pathology, Universitat Autònoma de Barcelona, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain.<br /><searchLink fieldCode="AU" term="%22Pericay+C%22">Pericay C</searchLink>; Medical Oncology Department, Mutua de Terrassa University Hospital, Terrassa (Barcelona), Spain.<br /><searchLink fieldCode="AU" term="%22Golda+T%22">Golda T</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Bellvitge University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kreisler+E%22">Kreisler E</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Bellvitge University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Espin-Basany+E%22">Espin-Basany E</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Vall d'Hebron University Hospital, Departamento de Cirugía, Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pallisera+A%22">Pallisera A</searchLink>; Department of Surgery, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell (Barcelona), Spain.<br /><searchLink fieldCode="AU" term="%22Badia-Closa+J%22">Badia-Closa J</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Espina+B%22">Espina B</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Santa Creu I Sant Pau University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Borda-Arrizabalaga+N%22">Borda-Arrizabalaga N</searchLink>; General and Digestive Surgery Department, Donostia University Hospital, Donostia, Gipuzkoa, Spain.<br /><searchLink fieldCode="AU" term="%22Reina+A%22">Reina A</searchLink>; Colorectal Unit, Unidad de Gestión Clínica Cirugía y Area de Gestión Norte de Almería, Complejo Hospitalario Torrecárdenas, Almería, Spain.<br /><searchLink fieldCode="AU" term="%22Guadalajara-Labajo+H%22">Guadalajara-Labajo H</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Otero+A%22">Otero A</searchLink>; General and Digestive Surgery Department, Hospital Clinic University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Delgado+S%22">Delgado S</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Mutua de Terrassa University Hospital, Terrassa (Barcelona), Spain.<br /><searchLink fieldCode="AU" term="%22Kraft+M%22">Kraft M</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Vall d'Hebron University Hospital, Departamento de Cirugía, Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Querol+R%22">Querol R</searchLink>; Department of Medical Oncology, Universitat Autònoma de Barcelona, Coloproctology Unit, Parc Tauli University Hospital, Institut d'investigació I Innovació Parc Tauli I3PT-CERCA, Sabadell, Spain.<br /><searchLink fieldCode="AU" term="%22Flor+B%22">Flor B</searchLink>; Colorectal Unit, General and Digestive Surgery Department, La Fe University Hospital, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Pellino+G%22">Pellino G</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Vall d'Hebron University Hospital, Departamento de Cirugía, Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Biondo+S%22">Biondo S</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Bellvitge University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Caro-Tarrago+A%22">Caro-Tarrago A</searchLink>; Colorectal Unit, General and Digestive Surgery Department, Joan XXIII University Hospital, Tarragona, Spain.
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  Data: <searchLink fieldCode="JN" term="%228607899%22">International journal of colorectal disease</searchLink> [Int J Colorectal Dis] 2026 Apr 23; Vol. 41 (1). <i>Date of Electronic Publication: </i>2026 Apr 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8607899 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1262 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201791958%22">01791958 </searchLink><i>NLM ISO Abbreviation: </i>Int J Colorectal Dis <i>Subsets: </i>MEDLINE
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