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Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization.

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Title: Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization.
Authors: Zaratiana C; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore., M Y; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore., Lee YA; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore., Ong ABL; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore., Liu TZY; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore., Low SMC; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore., Chang SMS; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore., Tan S; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore., Mustafa DNA; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore., Ganesh A; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Chang X; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore 119074, Singapore; Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Koh XQ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore., Tay SH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore., Lee WJJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore 119074, Singapore; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore., Yuan JM; University of Pittsburgh Medical Centre (UPMC), Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore; A(∗)STAR Institute for Human Development and Potential, Singapore 117609, Singapore., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore., Li YE; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Kasahara K; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore., Wuestefeld T; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore., Chen PB; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore 117574, Singapore. Electronic address: benson_chen@a-star.edu.sg.
Source: Molecular cell [Mol Cell] 2026 May 07; Vol. 86 (9), pp. 1708-1722.e9. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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  Data: Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization.
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  Data: <searchLink fieldCode="AU" term="%22Zaratiana+C%22">Zaratiana C</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22M+Y%22">M Y</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+YA%22">Lee YA</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+ABL%22">Ong ABL</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+TZY%22">Liu TZY</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Low+SMC%22">Low SMC</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Chang+SMS%22">Chang SMS</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+S%22">Tan S</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Mustafa+DNA%22">Mustafa DNA</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Ganesh+A%22">Ganesh A</searchLink>; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Chang+X%22">Chang X</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore 119074, Singapore; Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Koh+XQ%22">Koh XQ</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+SH%22">Tay SH</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+WJJ%22">Lee WJJ</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore 119074, Singapore; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore.<br /><searchLink fieldCode="AU" term="%22Yuan+JM%22">Yuan JM</searchLink>; University of Pittsburgh Medical Centre (UPMC), Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.<br /><searchLink fieldCode="AU" term="%22Khor+CC%22">Khor CC</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.<br /><searchLink fieldCode="AU" term="%22Koh+WP%22">Koh WP</searchLink>; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore; A(∗)STAR Institute for Human Development and Potential, Singapore 117609, Singapore.<br /><searchLink fieldCode="AU" term="%22Dorajoo+R%22">Dorajoo R</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+YE%22">Li YE</searchLink>; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Kasahara+K%22">Kasahara K</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Wuestefeld+T%22">Wuestefeld T</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+PB%22">Chen PB</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore 117574, Singapore. Electronic address: benson_chen@a-star.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2026 May 07; Vol. 86 (9), pp. 1708-1722.e9. <i>Date of Electronic Publication: </i>2026 Apr 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9802571 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4164 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210972765%22">10972765 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cell <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.molcel.2026.03.036
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              Text: 2026 May 07
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