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Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial.

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Title: Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial.
Authors: Debily MA; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France. marie-anne.debily@gustaveroussy.fr.; Department of Biology, University Evry Paris-Saclay, Evry, France. marie-anne.debily@gustaveroussy.fr., Le Teuff G; Department of Statistics and Epidemiology, Gustave Roussy, Villejuif, France., Kergrohen T; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France., Varlet P; Department of Neuropathology, Groupe Hospitalier Universitaire Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France., Castel D; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France., Leblond P; Institut d'Hématologie et d'Oncologie Pédiatrique, Centre Léon Bérard, Lyon and Unité d'oncologie pédiatrique, Centre Oscar Lambret, Lille, France., Hargrave D; Great Ormond Street Institute of Child Health, University College London, London, UK., Nysom K; Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Blomgren K; Department of Women's and Children's Health, Karolinska Institutet Stockholm, Stockholm, Sweden.; Pediatric Oncology, Karolinska University Hospital, Stockholm, Sweden., McCowage GB; Sydney Children's Hospitals Network, Westmead, New South Wales, Australia., Bautista F; Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Vuurden D; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Jones C; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Mackay A; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Izquierdo E; Division of Cancer Biology, The Institute of Cancer Research, London, UK.; Institute of Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Madrid, Spain.; CIBERER-ISCIII, IdiPAZ-CNIO Translational Research Unit in Pediatric Hemato-Oncology, La Paz University Hospital Research Institute, Spanish National Cancer Center, Madrid, Spain., Ziegler DS; Kids Cancer Centre, Sydney Children's Hospital, Randwick and School of Clinical Medicine, University of New South Wales and Children's Cancer Institute Australia, Lowy Cancer Research Centre, Sydney, New South Wales, Australia., Moussa A; Department of Statistics and Epidemiology, Gustave Roussy, Villejuif, France., Barret E; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France., Puget S; Pediatric Neurosurgery, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France., Beccaria K; Pediatric Neurosurgery, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France., Aquilina K; Department of Neurosurgery, Great Ormond Street Hospital, London, UK., Riffaud L; Department of Pediatric Neurosurgery, University Hospital, Rennes, France., Bolle S; Centro de Protonterapia Quironsalud, Madrid, Spain., Abbou S; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France.; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Bertozzi AI; Pediatric Oncology Department, Children's Hospital, Toulouse University Hospital, Toulouse, France., De Carli E; Department of Pediatric Oncology, University Hospital, Angers, France., Boddaert N; Pediatric Radiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades and INSERM ERL UA10, INSERM U1163, Institut Imagine, Paris, France., Dangouloff-Ros V; Pediatric Radiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades and INSERM ERL UA10, INSERM U1163, Institut Imagine, Paris, France., Calmon R; Pediatric Radiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades and INSERM ERL UA10, INSERM U1163, Institut Imagine, Paris, France., Blanc P; Charity Imagine for Margo, Paris, France., Vassal G; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France.; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Le Deley MC; Methodology and Biostatistics Unit, Centre Oscar Lambret, Lille, France., Grill J; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France. jacques.grill@gustaveroussy.fr.; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France. jacques.grill@gustaveroussy.fr.
Source: Nature medicine [Nat Med] 2026 Jun; Vol. 32 (6), pp. 2201-2215. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial.
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INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Leblond+P%22">Leblond P</searchLink>; Institut d'Hématologie et d'Oncologie Pédiatrique, Centre Léon Bérard, Lyon and Unité d'oncologie pédiatrique, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Hargrave+D%22">Hargrave D</searchLink>; Great Ormond Street Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nysom+K%22">Nysom K</searchLink>; Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Blomgren+K%22">Blomgren K</searchLink>; Department of Women's and Children's Health, Karolinska Institutet Stockholm, Stockholm, Sweden.; Pediatric Oncology, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22McCowage+GB%22">McCowage GB</searchLink>; 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CIBERER-ISCIII, IdiPAZ-CNIO Translational Research Unit in Pediatric Hemato-Oncology, La Paz University Hospital Research Institute, Spanish National Cancer Center, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ziegler+DS%22">Ziegler DS</searchLink>; Kids Cancer Centre, Sydney Children's Hospital, Randwick and School of Clinical Medicine, University of New South Wales and Children's Cancer Institute Australia, Lowy Cancer Research Centre, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Moussa+A%22">Moussa A</searchLink>; Department of Statistics and Epidemiology, Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Barret+E%22">Barret E</searchLink>; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Puget+S%22">Puget S</searchLink>; Pediatric Neurosurgery, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Beccaria+K%22">Beccaria K</searchLink>; Pediatric Neurosurgery, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Aquilina+K%22">Aquilina K</searchLink>; Department of Neurosurgery, Great Ormond Street Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Riffaud+L%22">Riffaud L</searchLink>; Department of Pediatric Neurosurgery, University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Bolle+S%22">Bolle S</searchLink>; Centro de Protonterapia Quironsalud, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Abbou+S%22">Abbou S</searchLink>; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France.; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Bertozzi+AI%22">Bertozzi AI</searchLink>; Pediatric Oncology Department, Children's Hospital, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22De+Carli+E%22">De Carli E</searchLink>; Department of Pediatric Oncology, University Hospital, Angers, France.<br /><searchLink fieldCode="AU" term="%22Boddaert+N%22">Boddaert N</searchLink>; Pediatric Radiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades and INSERM ERL UA10, INSERM U1163, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dangouloff-Ros+V%22">Dangouloff-Ros V</searchLink>; Pediatric Radiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades and INSERM ERL UA10, INSERM U1163, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Calmon+R%22">Calmon R</searchLink>; Pediatric Radiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Necker Enfants Malades and INSERM ERL UA10, INSERM U1163, Institut Imagine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Blanc+P%22">Blanc P</searchLink>; Charity Imagine for Margo, Paris, France.<br /><searchLink fieldCode="AU" term="%22Vassal+G%22">Vassal G</searchLink>; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France.; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Le+Deley+MC%22">Le Deley MC</searchLink>; Methodology and Biostatistics Unit, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Grill+J%22">Grill J</searchLink>; INSERM 1360, Gustave Roussy, Université Paris-Saclay, Oncogenesis, Resistance and Therapeutic Targets of Pediatric Cancers, Team 'Genomics and Oncogenesis of Pediatric Brain Tumors', Villejuif, France. jacques.grill@gustaveroussy.fr.; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France. jacques.grill@gustaveroussy.fr.
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