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Serum metabolic profile at clinical onset as predictor of multiple sclerosis activity and progression after 5 years.

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Title: Serum metabolic profile at clinical onset as predictor of multiple sclerosis activity and progression after 5 years.
Authors: Peng X; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Bjornevik K; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Clish CB; Metabolomics Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Edan G; CHU Hôpital Pontchaillou, Rennes, France., Freedman MS; Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada., Hartung HP; Department of Neurology, Medical Faculty, Heinrich-Heine Universität, Düsseldorf, Germany; Brain and Mind Center, Medical Faculty, The University of Sydney, Sydney NSW, Australia; Brain and Mind Centre, The University of Sydney, Sydney NSW, Australia; Department of Neurology, Palacky University Olomouc, Olomouc, Czechia., Montalbán X; Multiple Sclerosis Center of Catalonia (Cemcat), Vall d'Hebron University Hospital, Barcelona, Spain., Sandbrink R; Department of Neurology, Medical Faculty, Heinrich-Heine Universität, Düsseldorf, Germany; Sandbrink Drug Development Consulting & Clinical Services (SDDCCS), Berlin, Germany., Kuhle J; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Head, Spine and Neuromedicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland., Barkhof F; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK., Wicklein EM; Bayer AG, Berlin, Germany., Kappos L; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Head, Spine and Neuromedicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland., Ascherio A; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA., Cortese M; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Source: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2026 Jun; Vol. 32 (7), pp. 696-710. Date of Electronic Publication: 2026 Apr 26.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Serum metabolic profile at clinical onset as predictor of multiple sclerosis activity and progression after 5 years.
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  Data: <searchLink fieldCode="AU" term="%22Peng+X%22">Peng X</searchLink>; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bjornevik+K%22">Bjornevik K</searchLink>; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Clish+CB%22">Clish CB</searchLink>; Metabolomics Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Edan+G%22">Edan G</searchLink>; CHU Hôpital Pontchaillou, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Freedman+MS%22">Freedman MS</searchLink>; Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hartung+HP%22">Hartung HP</searchLink>; Department of Neurology, Medical Faculty, Heinrich-Heine Universität, Düsseldorf, Germany; Brain and Mind Center, Medical Faculty, The University of Sydney, Sydney NSW, Australia; Brain and Mind Centre, The University of Sydney, Sydney NSW, Australia; Department of Neurology, Palacky University Olomouc, Olomouc, Czechia.<br /><searchLink fieldCode="AU" term="%22Montalbán+X%22">Montalbán X</searchLink>; Multiple Sclerosis Center of Catalonia (Cemcat), Vall d'Hebron University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sandbrink+R%22">Sandbrink R</searchLink>; Department of Neurology, Medical Faculty, Heinrich-Heine Universität, Düsseldorf, Germany; Sandbrink Drug Development Consulting & Clinical Services (SDDCCS), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kuhle+J%22">Kuhle J</searchLink>; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Head, Spine and Neuromedicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Barkhof+F%22">Barkhof F</searchLink>; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wicklein+EM%22">Wicklein EM</searchLink>; Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kappos+L%22">Kappos L</searchLink>; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Departments of Head, Spine and Neuromedicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ascherio+A%22">Ascherio A</searchLink>; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cortese+M%22">Cortese M</searchLink>; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%229509185%22">Multiple sclerosis (Houndmills, Basingstoke, England)</searchLink> [Mult Scler] 2026 Jun; Vol. 32 (7), pp. 696-710. <i>Date of Electronic Publication: </i>2026 Apr 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9509185 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-0970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213524585%22">13524585 </searchLink><i>NLM ISO Abbreviation: </i>Mult Scler <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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