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Synthesis and characterization of chitosan-functionalized nanostructured lipid carriers with temozolomide: cytotoxic effects and chromosomal instability in human glioblastoma cells.

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Title: Synthesis and characterization of chitosan-functionalized nanostructured lipid carriers with temozolomide: cytotoxic effects and chromosomal instability in human glioblastoma cells.
Authors: Negreiros HA; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., do Lago JPAD; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., de Oliveira VA; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., Silva LRA; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., de Melo ACL; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., de Sousa IGB; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., da Cruz Esteves J; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., Francisco SEMC; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., Paiva SL; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., Rodrigues JPCG; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil., Carvalho LMM; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil., de Souza PHO; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil., Uchôa AFC; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil., Cardoso ALMR; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil., de Alencar Sales WF; Department of Biology, Federal University of Piauí, Teresina, Brazil., da Silva Bastos MH; Department of Biology, Federal University of Piauí, Teresina, Brazil., de Lima Feitoza L; Department of Biology, Federal University of Piauí, Teresina, Brazil., Júnior DD; Postgraduate Program in Pharmaceutical Sciences, Laboratory of Antineoplastic Pharmacology (LAFAN), Federal University of Piauí, Teresina, Brazil., da Silva FCC; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil., Xavier-Júnior FH; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil., Ferreira PMP; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil., de Castro E Sousa JM; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil. j.marcelo@ufpi.edu.br.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Apr 27. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: Synthesis and characterization of chitosan-functionalized nanostructured lipid carriers with temozolomide: cytotoxic effects and chromosomal instability in human glioblastoma cells.
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  Data: <searchLink fieldCode="AU" term="%22Negreiros+HA%22">Negreiros HA</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22do+Lago+JPAD%22">do Lago JPAD</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+VA%22">de Oliveira VA</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+LRA%22">Silva LRA</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Melo+ACL%22">de Melo ACL</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+IGB%22">de Sousa IGB</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Cruz+Esteves+J%22">da Cruz Esteves J</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22Francisco+SEMC%22">Francisco SEMC</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22Paiva+SL%22">Paiva SL</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+JPCG%22">Rodrigues JPCG</searchLink>; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.<br /><searchLink fieldCode="AU" term="%22Carvalho+LMM%22">Carvalho LMM</searchLink>; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+PHO%22">de Souza PHO</searchLink>; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.<br /><searchLink fieldCode="AU" term="%22Uchôa+AFC%22">Uchôa AFC</searchLink>; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.<br /><searchLink fieldCode="AU" term="%22Cardoso+ALMR%22">Cardoso ALMR</searchLink>; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Alencar+Sales+WF%22">de Alencar Sales WF</searchLink>; Department of Biology, Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Bastos+MH%22">da Silva Bastos MH</searchLink>; Department of Biology, Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Lima+Feitoza+L%22">de Lima Feitoza L</searchLink>; Department of Biology, Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22Júnior+DD%22">Júnior DD</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Laboratory of Antineoplastic Pharmacology (LAFAN), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+FCC%22">da Silva FCC</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22Xavier-Júnior+FH%22">Xavier-Júnior FH</searchLink>; Pharmaceutical Biotechnology Laboratory (BioTecFarm), Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+PMP%22">Ferreira PMP</searchLink>; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Castro+E+Sousa+JM%22">de Castro E Sousa JM</searchLink>; Postgraduate Program in Pharmaceutical Sciences, Toxicological Genetics Research Laboratory (Lapgenic), Federal University of Piauí, Teresina, Brazil. j.marcelo@ufpi.edu.br.
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