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XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease.

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Title: XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease.
Authors: Fang R; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China., Wang W; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China., Zhang L; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Huang J; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China., Huang L; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Wu H; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China., Qi Y; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Li L; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Tan L; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Zhang M; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China., Zhu J; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Peng X; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China., Zhong K; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Zou M; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Yang X; Department of Rheumatology and Immunology Children's Hospital of Chongqing Medical University Chongqing China., Wang Q; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China., Nie C; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China., Tang C; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China., Tang N; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China., Geng L; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Chen H; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Vince JE; The Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology University of Melbourne Parkville, Vic Australia., Kanegane H; Department of Child Health and Development Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan., Zhao X; Department of Rheumatology and Immunology Children's Hospital of Chongqing Medical University Chongqing China., Xian H; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Zhou W; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Zhi M; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China., Zhang Y; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China., Chen Z; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.
Source: MedComm [MedComm (2020)] 2026 Apr 25; Vol. 7, pp. e70745. Date of Electronic Publication: 2026 Apr 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: China NLM ID: 101769925 Publication Model: eCollection Cited Medium: Internet ISSN: 2688-2663 (Electronic) Linking ISSN: 26882663 NLM ISO Abbreviation: MedComm (2020) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Fang+R%22">Fang R</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Qi+Y%22">Qi Y</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Peng+X%22">Peng X</searchLink>; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhong+K%22">Zhong K</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zou+M%22">Zou M</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Rheumatology and Immunology Children's Hospital of Chongqing Medical University Chongqing China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.<br /><searchLink fieldCode="AU" term="%22Nie+C%22">Nie C</searchLink>; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.<br /><searchLink fieldCode="AU" term="%22Tang+C%22">Tang C</searchLink>; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.<br /><searchLink fieldCode="AU" term="%22Tang+N%22">Tang N</searchLink>; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.<br /><searchLink fieldCode="AU" term="%22Geng+L%22">Geng L</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Vince+JE%22">Vince JE</searchLink>; The Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology University of Melbourne Parkville, Vic Australia.<br /><searchLink fieldCode="AU" term="%22Kanegane+H%22">Kanegane H</searchLink>; Department of Child Health and Development Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Rheumatology and Immunology Children's Hospital of Chongqing Medical University Chongqing China.<br /><searchLink fieldCode="AU" term="%22Xian+H%22">Xian H</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhi+M%22">Zhi M</searchLink>; Department of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Clinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.; Department of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.
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