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Conducting a randomized controlled clinical trial on palliative care in patients with glioblastoma - what are the challenges?

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Title: Conducting a randomized controlled clinical trial on palliative care in patients with glioblastoma - what are the challenges?
Authors: Joshi M; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany. Melanie.Joshi@uk-koeln.de., Nettekoven C; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital, Department of Neurosurgery, Cologne, Germany., Kochs S; University of Cologne, Faculty of Medicine and University Hospital, Department of Neurosurgery, Cologne, Germany., Appelmann I; RWTH Aachen University, Medical Faculty, Department of Palliative Medicine, Aachen, Germany., Bausewein C; University of Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Palliative Medicine, Munich, Germany., Becker G; University of Freiburg, Faculty of Medicine, Department of Palliative Medicine, Freiburg, Germany., Boehlke C; University of Freiburg, Faculty of Medicine, Department of Palliative Medicine, Freiburg, Germany., Brumbarova T; University of Cologne, Clinical Trial Centre Cologne (ZKS), Cologne, Germany., Civello D; University of Cologne, Faculty of Medicine and University Hospital, Institute of Health Economics and Clinical Epidemiology (IGKE), Cologne, Germany., Clusmann H; RWTH Aachen University, Medical Faculty, Department of Neurosurgery, Aachen, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany., Goldbrunner R; University of Cologne, Faculty of Medicine and University Hospital, Department of Neurosurgery, Cologne, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany., Haberland B; University of Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Palliative Medicine, Munich, Germany., Heiland DH; University of Freiburg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Freiburg, Germany.; Friedrich-Alexander-University Erlangen-Nurnberg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Erlangen, Germany.; Northwestern University Feinberg School of Medicine and Malnati Brain Tumor Institute, Northwestern Medicine, Department of Neurological Surgery, Chicago, USA., Hellmich M; University of Cologne, Faculty of Medicine, Institute of Medical Statistics and Computational Biology (IMSB), Cologne, Germany.; University Medical Center Göttingen, Department of Medical Statistics, Göttingen, Germany., Herrlinger U; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Bonn, University Hospital Bonn, Center for Neurology, Department of Neurooncology, Bonn, Germany., Jaspers B; University of Bonn, University Hospital Bonn, Department of Palliative Medicine, Bonn, Germany.; University Medical Center Göttingen, Department of Palliative Medicine, Göttingen, Germany., Müller D; University of Cologne, Faculty of Medicine and University Hospital, Institute of Health Economics and Clinical Epidemiology (IGKE), Cologne, Germany., Müller W; University of Cologne, Faculty of Medicine, Institute of Medical Statistics and Computational Biology (IMSB), Cologne, Germany., Na CH; RWTH Aachen University, Medical Faculty, Department of Neurosurgery, Aachen, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany., Neukirchen M; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; Heinrich-Heine-University Düsseldorf, University Hospital Düsseldorf, Interdisciplinary Centre of Palliative Medicine, Düsseldorf, Germany.; Heinrich-Heine-University Düsseldorf, University Hospital Düsseldorf, Department of Anaesthesiology, Düsseldorf, Germany., Radbruch L; University of Bonn, University Hospital Bonn, Department of Palliative Medicine, Bonn, Germany., Rapp M; Beta-Klinik Bonn, Center for Neuro-Oncological Neurosurgery, Bonn, Germany.; Heinrich-Heine-University, Düsseldorf, University Hospital Düsseldorf, Department of Neurosurgery, Düsseldorf, Germany., Rolke R; RWTH Aachen University, Medical Faculty, Department of Palliative Medicine, Aachen, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany., Ruge MI; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Cologne, Faculty of Medicine and University Hospital, Center for Neurosurgery, Department of Stereotaxy and Functional Neurosurgery, Cologne, Germany., Sabel M; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; Beta-Klinik Bonn, Center for Neuro-Oncological Neurosurgery, Bonn, Germany.; Heinrich-Heine-University, Düsseldorf, University Hospital Düsseldorf, Department of Neurosurgery, Düsseldorf, Germany., Schnell O; University of Freiburg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Freiburg, Germany.; Friedrich-Alexander-University Erlangen-Nurnberg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Erlangen, Germany., Schwartz J; Heinrich-Heine-University Düsseldorf, University Hospital Düsseldorf, Interdisciplinary Centre of Palliative Medicine, Düsseldorf, Germany., Thon N; University Hospital Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Neurosurgery, Munich, Germany., Vatter H; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Bonn, University Hospital Bonn, Department of Neurosurgery, Bonn, Germany., von Baumgarten L; University Hospital Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Neurosurgery, Munich, Germany., Voltz R; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Cologne, Faculty of Medicine and University Hospital, Center for Health Services Research Cologne (ZVFK), University of Cologne, Cologne, Germany., Golla H; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany.; University Medical Center Göttingen, Department of Palliative Medicine, Göttingen, Germany.
Corporate Authors: EPCOG Study Group
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2026 Apr 27; Vol. 34 (5). Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Conducting a randomized controlled clinical trial on palliative care in patients with glioblastoma - what are the challenges?
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  Data: <searchLink fieldCode="AU" term="%22Joshi+M%22">Joshi M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany. Melanie.Joshi@uk-koeln.de.<br /><searchLink fieldCode="AU" term="%22Nettekoven+C%22">Nettekoven C</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital, Department of Neurosurgery, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kochs+S%22">Kochs S</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Department of Neurosurgery, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Appelmann+I%22">Appelmann I</searchLink>; RWTH Aachen University, Medical Faculty, Department of Palliative Medicine, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Bausewein+C%22">Bausewein C</searchLink>; University of Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Palliative Medicine, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+G%22">Becker G</searchLink>; University of Freiburg, Faculty of Medicine, Department of Palliative Medicine, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boehlke+C%22">Boehlke C</searchLink>; University of Freiburg, Faculty of Medicine, Department of Palliative Medicine, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Brumbarova+T%22">Brumbarova T</searchLink>; University of Cologne, Clinical Trial Centre Cologne (ZKS), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Civello+D%22">Civello D</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Institute of Health Economics and Clinical Epidemiology (IGKE), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Clusmann+H%22">Clusmann H</searchLink>; RWTH Aachen University, Medical Faculty, Department of Neurosurgery, Aachen, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Goldbrunner+R%22">Goldbrunner R</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Department of Neurosurgery, Cologne, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Haberland+B%22">Haberland B</searchLink>; University of Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Palliative Medicine, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heiland+DH%22">Heiland DH</searchLink>; University of Freiburg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Freiburg, Germany.; Friedrich-Alexander-University Erlangen-Nurnberg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Erlangen, Germany.; Northwestern University Feinberg School of Medicine and Malnati Brain Tumor Institute, Northwestern Medicine, Department of Neurological Surgery, Chicago, USA.<br /><searchLink fieldCode="AU" term="%22Hellmich+M%22">Hellmich M</searchLink>; University of Cologne, Faculty of Medicine, Institute of Medical Statistics and Computational Biology (IMSB), Cologne, Germany.; University Medical Center Göttingen, Department of Medical Statistics, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Herrlinger+U%22">Herrlinger U</searchLink>; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Bonn, University Hospital Bonn, Center for Neurology, Department of Neurooncology, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Jaspers+B%22">Jaspers B</searchLink>; University of Bonn, University Hospital Bonn, Department of Palliative Medicine, Bonn, Germany.; University Medical Center Göttingen, Department of Palliative Medicine, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+D%22">Müller D</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Institute of Health Economics and Clinical Epidemiology (IGKE), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+W%22">Müller W</searchLink>; University of Cologne, Faculty of Medicine, Institute of Medical Statistics and Computational Biology (IMSB), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Na+CH%22">Na CH</searchLink>; RWTH Aachen University, Medical Faculty, Department of Neurosurgery, Aachen, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Neukirchen+M%22">Neukirchen M</searchLink>; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; Heinrich-Heine-University Düsseldorf, University Hospital Düsseldorf, Interdisciplinary Centre of Palliative Medicine, Düsseldorf, Germany.; Heinrich-Heine-University Düsseldorf, University Hospital Düsseldorf, Department of Anaesthesiology, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Radbruch+L%22">Radbruch L</searchLink>; University of Bonn, University Hospital Bonn, Department of Palliative Medicine, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Rapp+M%22">Rapp M</searchLink>; Beta-Klinik Bonn, Center for Neuro-Oncological Neurosurgery, Bonn, Germany.; Heinrich-Heine-University, Düsseldorf, University Hospital Düsseldorf, Department of Neurosurgery, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Rolke+R%22">Rolke R</searchLink>; RWTH Aachen University, Medical Faculty, Department of Palliative Medicine, Aachen, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Ruge+MI%22">Ruge MI</searchLink>; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Cologne, Faculty of Medicine and University Hospital, Center for Neurosurgery, Department of Stereotaxy and Functional Neurosurgery, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sabel+M%22">Sabel M</searchLink>; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; Beta-Klinik Bonn, Center for Neuro-Oncological Neurosurgery, Bonn, Germany.; Heinrich-Heine-University, Düsseldorf, University Hospital Düsseldorf, Department of Neurosurgery, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Schnell+O%22">Schnell O</searchLink>; University of Freiburg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Freiburg, Germany.; Friedrich-Alexander-University Erlangen-Nurnberg, Faculty of Medicine and University Hospital, Department of Neurosurgery, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Schwartz+J%22">Schwartz J</searchLink>; Heinrich-Heine-University Düsseldorf, University Hospital Düsseldorf, Interdisciplinary Centre of Palliative Medicine, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Thon+N%22">Thon N</searchLink>; University Hospital Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Neurosurgery, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vatter+H%22">Vatter H</searchLink>; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Bonn, University Hospital Bonn, Department of Neurosurgery, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22von+Baumgarten+L%22">von Baumgarten L</searchLink>; University Hospital Munich (LMU), Faculty of Medicine and LMU University Hospital, Department of Neurosurgery, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Voltz+R%22">Voltz R</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany.; Center for Integrated Oncology, (CIO ABCD), Aachen Bonn Cologne Duesseldorf, Germany.; University of Cologne, Faculty of Medicine and University Hospital, Center for Health Services Research Cologne (ZVFK), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Golla+H%22">Golla H</searchLink>; University of Cologne, Faculty of Medicine and University Hospital, Department of Palliative Medicine, Cologne, Germany.; University Medical Center Göttingen, Department of Palliative Medicine, Göttingen, Germany.
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