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Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans.

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Title: Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans.
Authors: Lin YH; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan., Liao YH; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan., Liao SB; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan., Lin TY; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan., Shanmugam MM; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211, Kuopio, Finland., Hsu PJ; Department of Life Science, National Tsing Hua University, Hsinchu, 300044, Taiwan., Chen CS; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Ching TT; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan., Wagner OI; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan., Yuh CH; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan. chyuh@nhri.edu.tw.; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, 35053, Taiwan. chyuh@nhri.edu.tw., Wang HD; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan. hdwang@life.nthu.edu.tw.; Department of Life Science, National Tsing Hua University, Hsinchu, 300044, Taiwan. hdwang@life.nthu.edu.tw.
Source: Journal of biomedical science [J Biomed Sci] 2026 Apr 27; Vol. 33 (1). Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans.
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  Data: <searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+YH%22">Liao YH</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liao+SB%22">Liao SB</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+TY%22">Lin TY</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shanmugam+MM%22">Shanmugam MM</searchLink>; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hsu+PJ%22">Hsu PJ</searchLink>; Department of Life Science, National Tsing Hua University, Hsinchu, 300044, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CS%22">Chen CS</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ching+TT%22">Ching TT</searchLink>; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wagner+OI%22">Wagner OI</searchLink>; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yuh+CH%22">Yuh CH</searchLink>; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan. chyuh@nhri.edu.tw.; Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, 35053, Taiwan. chyuh@nhri.edu.tw.<br /><searchLink fieldCode="AU" term="%22Wang+HD%22">Wang HD</searchLink>; Institute of Biotechnology, National Tsing Hua University, Hsinchu, 300044, Taiwan. hdwang@life.nthu.edu.tw.; Department of Life Science, National Tsing Hua University, Hsinchu, 300044, Taiwan. hdwang@life.nthu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%229421567%22">Journal of biomedical science</searchLink> [J Biomed Sci] 2026 Apr 27; Vol. 33 (1). <i>Date of Electronic Publication: </i>2026 Apr 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421567 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1423-0127 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210217770%22">10217770 </searchLink><i>NLM ISO Abbreviation: </i>J Biomed Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12929-026-01246-x
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        Text: English
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      – TitleFull: Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans.
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            – D: 27
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              Text: 2026 Apr 27
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