Reduced versus standard dosing of Janus kinase inhibitors in rheumatoid arthritis: a propensity score-matched real-world study accounting for poor prognostic factors.

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Title: Reduced versus standard dosing of Janus kinase inhibitors in rheumatoid arthritis: a propensity score-matched real-world study accounting for poor prognostic factors.
Authors: Nozaki Y; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan. Electronic address: yuji0516@med.kindai.ac.jp., Shiga T; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Ri J; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Itami T; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Tomita D; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Yamazawa H; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Morimoto Y; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Fukuda R; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Tsuchimoto T; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Morita S; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Akazawa H; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Murata K; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Onishi A; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ebina K; Department of Orthopedic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan., Shirasugi I; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kobe University, Kobe, Japan., Yamada H; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kobe University, Kobe, Japan., Hashimoto M; Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Watanabe R; Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Wada Y; Department of Internal Medicine (IV), Division of Rheumatology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan., Takeuchi T; Department of Internal Medicine (IV), Division of Rheumatology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan., Amuro H; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan., Tanaka A; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan., Katayama M; Department of Rheumatology, Osaka Red Cross Hospital, Osaka, Japan., Etani Y; Department of Sports Medical Biomechanics, Graduate School of Medicine, The University of Osaka, Suita, Japan., Yamamoto W; Department of Health Information Management, Kurashiki Sweet Hospital, Kurashiki, Japan., Kinoshita K; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan., Rai S; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2026 Apr 27. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reduced versus standard dosing of Janus kinase inhibitors in rheumatoid arthritis: a propensity score-matched real-world study accounting for poor prognostic factors.
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  Data: <searchLink fieldCode="AU" term="%22Nozaki+Y%22">Nozaki Y</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan. Electronic address: yuji0516@med.kindai.ac.jp.<br /><searchLink fieldCode="AU" term="%22Shiga+T%22">Shiga T</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Ri+J%22">Ri J</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Itami+T%22">Itami T</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Tomita+D%22">Tomita D</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Yamazawa+H%22">Yamazawa H</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Morimoto+Y%22">Morimoto Y</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuda+R%22">Fukuda R</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuchimoto+T%22">Tsuchimoto T</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Morita+S%22">Morita S</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Akazawa+H%22">Akazawa H</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Murata+K%22">Murata K</searchLink>; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Onishi+A%22">Onishi A</searchLink>; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ebina+K%22">Ebina K</searchLink>; Department of Orthopedic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Shirasugi+I%22">Shirasugi I</searchLink>; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kobe University, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+H%22">Yamada H</searchLink>; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kobe University, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Hashimoto+M%22">Hashimoto M</searchLink>; Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+R%22">Watanabe R</searchLink>; Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Wada+Y%22">Wada Y</searchLink>; Department of Internal Medicine (IV), Division of Rheumatology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.<br /><searchLink fieldCode="AU" term="%22Takeuchi+T%22">Takeuchi T</searchLink>; Department of Internal Medicine (IV), Division of Rheumatology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.<br /><searchLink fieldCode="AU" term="%22Amuro+H%22">Amuro H</searchLink>; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+A%22">Tanaka A</searchLink>; First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Katayama+M%22">Katayama M</searchLink>; Department of Rheumatology, Osaka Red Cross Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Etani+Y%22">Etani Y</searchLink>; Department of Sports Medical Biomechanics, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+W%22">Yamamoto W</searchLink>; Department of Health Information Management, Kurashiki Sweet Hospital, Kurashiki, Japan.<br /><searchLink fieldCode="AU" term="%22Kinoshita+K%22">Kinoshita K</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Rai+S%22">Rai S</searchLink>; Department of Hematology and Rheumatology, Kindai University School of Medicine, Sakai, Japan; Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372355 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-2060 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200034967%22">00034967 </searchLink><i>NLM ISO Abbreviation: </i>Ann Rheum Dis <i>Subsets: </i>MEDLINE
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