Optimizing metabolic management on integrase-based ART (OPTIMAR): study protocol for a 2 × 2 factorial, randomised, double-blind placebo-controlled trial to compare the addition of dapagliflozin versus placebo, and rosuvastatin plus ezetimibe versus pitavastatin, in people with HIV on integrase strand transfer inhibitor-based antiretroviral therapy with elevated metabolic risk. - Nyein PP; Haskelberg H; Martinello M; Lowe M; Goodman-Meza D; Avihingsanon A; Kelleher AD; Rodgers A; Schutte AE; Nnakelu EC; Byakwaga H; Trevillyan J; et al. (Trials, 2026)