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Predictors of prolonged progression-free survival in patients with unresectable or recurrent pancreatic cancer treated with nanoliposomal irinotecan with fluorouracil and folinic acid (NAPOLEON-2 study).

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Title: Predictors of prolonged progression-free survival in patients with unresectable or recurrent pancreatic cancer treated with nanoliposomal irinotecan with fluorouracil and folinic acid (NAPOLEON-2 study).
Authors: Kawaguchi Y; Department of Gastroenterology, Asakura Medical Association Hospital, Fukuoka, Japan., Hayashi K; Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Shimokawa M; Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan.; Department of Biostatistics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan., Otsuka T; Department of Internal Medicine, Minato Medical Clinic, Fukuoka, Japan., Nakazawa J; Department of Medical Oncology, Kagoshima City Hospital, Kagoshima, Japan., Shimokawa H; Department of Hematology and Oncology, Japan Community Healthcare Organization Kyushu Hospital, Fukuoka, Japan.; Department of Medical Oncology, Hamanomachi Hospital, Fukuoka, Japan., Shinohara Y; Department of Hematology and Oncology, Japan Community Healthcare Organization Kyushu Hospital, Fukuoka, Japan., Koga F; Department of Hepatobiliary and Pancreatology, Saga Medical Center Koseikan, Saga, Japan., Oza N; Department of Hepatobiliary and Pancreatology, Saga Medical Center Koseikan, Saga, Japan., Oda H; Division of Integrative Medical Oncology, Saiseikai Kumamoto Hospital, Kumamoto, Japan., Takeshita S; Department of Gastroenterology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan., Arima S; Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan., Arita S; Department of Chemotherapy, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan., Nishikawa K; Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan., Otsu S; Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan., Taguchi H; Department of Gastroenterology, Imamura General Hospital, Kagoshima, Japan.; Department of Gastroenterology, Kagoshima City Hospital, Kagoshima, Japan., Jikuya K; Department of Gastroenterology, Imamura General Hospital, Kagoshima, Japan., Sakai T; Department of Medical Oncology, NHO Kumamoto Medical Center, Kumamoto, Japan., Ueda Y; Department of Hematology and Oncology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan., Sakae T; Department of Gastroenterology, Saiseikai Sendai Hospital, Kagoshima, Japan., Araki N; Department of Gastroenterology, Saiseikai Sendai Hospital, Kagoshima, Japan.; Department of Gastroenterology, Izumi General Medical Center, Kagoshima, Japan., Sawase H; Department of Internal Medicine, National Hospital Organization Saga Hospital, Saga, Japan., Ide Y; Department of Internal Medicine, National Hospital Organization Saga Hospital, Saga, Japan., Kawahira M; Department of Gastroenterology, Kagoshima Kouseiren Hospital, Kagoshima, Japan., Nio K; Department of Medical Oncology, Hamanomachi Hospital, Fukuoka, Japan., Shirakawa T; Clinical Hematology Oncology Treatment Study Group, 1-14-6 Muromi-gaoka, Nishi-ku, Fukuoka-shi, Fukuoka 819-0030, Japan.; Medical Checkup Center, Eikoh Hospital, 3-8-15 Befu-nishi, Shime-machi, Kasuya-gun, Fukuoka 811-2232, Japan., Mizuta T; Department of Internal Medicine, Fujikawa Hospital, Saga, Japan., Mitsugi K; Department of Medical Oncology, Sasebo Kyosai Hospital, Nagasaki, Japan.
Source: Therapeutic advances in medical oncology [Ther Adv Med Oncol] 2026 Apr 21; Vol. 18, pp. 17588359261442386. Date of Electronic Publication: 2026 Apr 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Sage Country of Publication: England NLM ID: 101510808 Publication Model: eCollection Cited Medium: Print ISSN: 1758-8340 (Print) Linking ISSN: 17588340 NLM ISO Abbreviation: Ther Adv Med Oncol Subsets: PubMed not MEDLINE
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  Data: Predictors of prolonged progression-free survival in patients with unresectable or recurrent pancreatic cancer treated with nanoliposomal irinotecan with fluorouracil and folinic acid (NAPOLEON-2 study).
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  Data: <searchLink fieldCode="AU" term="%22Kawaguchi+Y%22">Kawaguchi Y</searchLink>; Department of Gastroenterology, Asakura Medical Association Hospital, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+K%22">Hayashi K</searchLink>; Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Shimokawa+M%22">Shimokawa M</searchLink>; Clinical Research Institute, National Kyushu Cancer Center, Fukuoka, Japan.; Department of Biostatistics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Otsuka+T%22">Otsuka T</searchLink>; Department of Internal Medicine, Minato Medical Clinic, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakazawa+J%22">Nakazawa J</searchLink>; Department of Medical Oncology, Kagoshima City Hospital, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Shimokawa+H%22">Shimokawa H</searchLink>; Department of Hematology and Oncology, Japan Community Healthcare Organization Kyushu Hospital, Fukuoka, Japan.; Department of Medical Oncology, Hamanomachi Hospital, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Shinohara+Y%22">Shinohara Y</searchLink>; Department of Hematology and Oncology, Japan Community Healthcare Organization Kyushu Hospital, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Koga+F%22">Koga F</searchLink>; Department of Hepatobiliary and Pancreatology, Saga Medical Center Koseikan, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Oza+N%22">Oza N</searchLink>; Department of Hepatobiliary and Pancreatology, Saga Medical Center Koseikan, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Oda+H%22">Oda H</searchLink>; Division of Integrative Medical Oncology, Saiseikai Kumamoto Hospital, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Takeshita+S%22">Takeshita S</searchLink>; Department of Gastroenterology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Arima+S%22">Arima S</searchLink>; Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Arita+S%22">Arita S</searchLink>; Department of Chemotherapy, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nishikawa+K%22">Nishikawa K</searchLink>; Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan.<br /><searchLink fieldCode="AU" term="%22Otsu+S%22">Otsu S</searchLink>; Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan.<br /><searchLink fieldCode="AU" term="%22Taguchi+H%22">Taguchi H</searchLink>; Department of Gastroenterology, Imamura General Hospital, Kagoshima, Japan.; Department of Gastroenterology, Kagoshima City Hospital, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Jikuya+K%22">Jikuya K</searchLink>; Department of Gastroenterology, Imamura General Hospital, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Sakai+T%22">Sakai T</searchLink>; Department of Medical Oncology, NHO Kumamoto Medical Center, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ueda+Y%22">Ueda Y</searchLink>; Department of Hematology and Oncology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sakae+T%22">Sakae T</searchLink>; Department of Gastroenterology, Saiseikai Sendai Hospital, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Araki+N%22">Araki N</searchLink>; Department of Gastroenterology, Saiseikai Sendai Hospital, Kagoshima, Japan.; Department of Gastroenterology, Izumi General Medical Center, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Sawase+H%22">Sawase H</searchLink>; Department of Internal Medicine, National Hospital Organization Saga Hospital, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Ide+Y%22">Ide Y</searchLink>; Department of Internal Medicine, National Hospital Organization Saga Hospital, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Kawahira+M%22">Kawahira M</searchLink>; Department of Gastroenterology, Kagoshima Kouseiren Hospital, Kagoshima, Japan.<br /><searchLink fieldCode="AU" term="%22Nio+K%22">Nio K</searchLink>; Department of Medical Oncology, Hamanomachi Hospital, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Shirakawa+T%22">Shirakawa T</searchLink>; Clinical Hematology Oncology Treatment Study Group, 1-14-6 Muromi-gaoka, Nishi-ku, Fukuoka-shi, Fukuoka 819-0030, Japan.; Medical Checkup Center, Eikoh Hospital, 3-8-15 Befu-nishi, Shime-machi, Kasuya-gun, Fukuoka 811-2232, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuta+T%22">Mizuta T</searchLink>; Department of Internal Medicine, Fujikawa Hospital, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Mitsugi+K%22">Mitsugi K</searchLink>; Department of Medical Oncology, Sasebo Kyosai Hospital, Nagasaki, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101510808%22">Therapeutic advances in medical oncology</searchLink> [Ther Adv Med Oncol] 2026 Apr 21; Vol. 18, pp. 17588359261442386. <i>Date of Electronic Publication: </i>2026 Apr 21 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Sage%22">Sage </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101510808 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1758-8340 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217588340%22">17588340 </searchLink><i>NLM ISO Abbreviation: </i>Ther Adv Med Oncol <i>Subsets: </i>PubMed not MEDLINE
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