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Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease.

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Title: Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease.
Authors: Western D; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Yang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Timsina J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Liu M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Wang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Campbell MC; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Kotzbauer P; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA., Perlmutter JS; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Departments of Neuroscience and Radiology, Programs in Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA., Schindler SE; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Alvarez I; Neurosciences, Germans Trias I Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain., Pastor P; Neurosciences, Germans Trias I Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain.; Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias I Pujol and the Germans Trias I Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain., Wyss-Coray T; Department of Neurology, Stanford University, Stanford, CA 94304, USA., Marquié M; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.; CIBERNED, Center for Networked Biomedical Research On Neurodegenerative Diseases, National Institute of Health Carlos III, 28029 Madrid, Spain., Cano A; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain., Sung YJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., de Rojas I; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.; CIBERNED, Center for Networked Biomedical Research On Neurodegenerative Diseases, National Institute of Health Carlos III, 28029 Madrid, Spain., Ruiz A; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.; CIBERNED, Center for Networked Biomedical Research On Neurodegenerative Diseases, National Institute of Health Carlos III, 28029 Madrid, Spain.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA., Budde J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Fernandez MV; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain., Tarawneh R; Department of Neurology, Saint Louis University, St. Louis, MO 63104, USA., Ibanez L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Apr 29; Vol. 18 (847), pp. eadz2016. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease.
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  Data: <searchLink fieldCode="AU" term="%22Western+D%22">Western D</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Timsina+J%22">Timsina J</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+MC%22">Campbell MC</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Kotzbauer+P%22">Kotzbauer P</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Perlmutter+JS%22">Perlmutter JS</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Departments of Neuroscience and Radiology, Programs in Physical Therapy and Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Schindler+SE%22">Schindler SE</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez+I%22">Alvarez I</searchLink>; Neurosciences, Germans Trias I Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pastor+P%22">Pastor P</searchLink>; Neurosciences, Germans Trias I Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain.; Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias I Pujol and the Germans Trias I Pujol Research Institute (IGTP), 08916 Badalona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wyss-Coray+T%22">Wyss-Coray T</searchLink>; Department of Neurology, Stanford University, Stanford, CA 94304, USA.<br /><searchLink fieldCode="AU" term="%22Marquié+M%22">Marquié M</searchLink>; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.; CIBERNED, Center for Networked Biomedical Research On Neurodegenerative Diseases, National Institute of Health Carlos III, 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cano+A%22">Cano A</searchLink>; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sung+YJ%22">Sung YJ</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22de+Rojas+I%22">de Rojas I</searchLink>; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.; CIBERNED, Center for Networked Biomedical Research On Neurodegenerative Diseases, National Institute of Health Carlos III, 28029 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ruiz+A%22">Ruiz A</searchLink>; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.; CIBERNED, Center for Networked Biomedical Research On Neurodegenerative Diseases, National Institute of Health Carlos III, 28029 Madrid, Spain.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.<br /><searchLink fieldCode="AU" term="%22Budde+J%22">Budde J</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Fernandez+MV%22">Fernandez MV</searchLink>; ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08028 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tarawneh+R%22">Tarawneh R</searchLink>; Department of Neurology, Saint Louis University, St. Louis, MO 63104, USA.<br /><searchLink fieldCode="AU" term="%22Ibanez+L%22">Ibanez L</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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