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From necroptosis to neuroinflammation: Unraveling mechanisms and therapeutic targets in age-related cognitive decline.

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Title: From necroptosis to neuroinflammation: Unraveling mechanisms and therapeutic targets in age-related cognitive decline.
Authors: Biscetti L; Section of Neurology, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: l.biscetti@inrca.it., Gambuzza ME; Independent Researcher, Messina 98122, Italy. Electronic address: gambuzza2002@yahoo.it., Princiotto M; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: m.princiotto@inrca.it., Sabbatinelli J; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona 60124, Italy; Clinic of Laboratory and Precision Medicine, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: j.sabbatinelli@staff.univpm.it., Olivieri F; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona 60124, Italy; Advanced Technology Center for Aging Research, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: f.olivieri@staff.univpm.it., Fiorillo M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende 87036, Italy. Electronic address: marco.fiorillo@unical.it., Chinigò C; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: c.chinigo@inrca.it., Muglia L; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: l.muglia@inrca.it., Cozza A; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: a.cozza@inrca.it., Beccacece A; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: a.beccacece@inrca.it., Gembillo G; Department of Clinical and Experimental Medicine, Unit of Nephrology and Dialysis, University of Messina, Messina 90125, Italy. Electronic address: guidogembillo@live.it., Bruschetta G; Department of Veterinary Sciences, University of Messina, Messina 98168, Italy. Electronic address: giuseppe.bruschetta@unime.it., Villalta Savedra E; Independent Researcher, Castrolibero 87040, Italy. Electronic address: edlinvillalta@gmail.com., Lattanzio F; Scientific Direction, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: f.lattanzio@inrca.it., Corsonello A; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende 87036, Italy; Unit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: a.corsonello@inrca.it., Soraci L; Unit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: l.soraci@inrca.it.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119326. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article; Review
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: From necroptosis to neuroinflammation: Unraveling mechanisms and therapeutic targets in age-related cognitive decline.
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  Data: <searchLink fieldCode="AU" term="%22Biscetti+L%22">Biscetti L</searchLink>; Section of Neurology, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: l.biscetti@inrca.it.<br /><searchLink fieldCode="AU" term="%22Gambuzza+ME%22">Gambuzza ME</searchLink>; Independent Researcher, Messina 98122, Italy. Electronic address: gambuzza2002@yahoo.it.<br /><searchLink fieldCode="AU" term="%22Princiotto+M%22">Princiotto M</searchLink>; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: m.princiotto@inrca.it.<br /><searchLink fieldCode="AU" term="%22Sabbatinelli+J%22">Sabbatinelli J</searchLink>; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona 60124, Italy; Clinic of Laboratory and Precision Medicine, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: j.sabbatinelli@staff.univpm.it.<br /><searchLink fieldCode="AU" term="%22Olivieri+F%22">Olivieri F</searchLink>; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona 60124, Italy; Advanced Technology Center for Aging Research, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: f.olivieri@staff.univpm.it.<br /><searchLink fieldCode="AU" term="%22Fiorillo+M%22">Fiorillo M</searchLink>; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende 87036, Italy. Electronic address: marco.fiorillo@unical.it.<br /><searchLink fieldCode="AU" term="%22Chinigò+C%22">Chinigò C</searchLink>; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: c.chinigo@inrca.it.<br /><searchLink fieldCode="AU" term="%22Muglia+L%22">Muglia L</searchLink>; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: l.muglia@inrca.it.<br /><searchLink fieldCode="AU" term="%22Cozza+A%22">Cozza A</searchLink>; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: a.cozza@inrca.it.<br /><searchLink fieldCode="AU" term="%22Beccacece+A%22">Beccacece A</searchLink>; Centre for Biostatistics and Applied Geriatric Clinical Epidemiology, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: a.beccacece@inrca.it.<br /><searchLink fieldCode="AU" term="%22Gembillo+G%22">Gembillo G</searchLink>; Department of Clinical and Experimental Medicine, Unit of Nephrology and Dialysis, University of Messina, Messina 90125, Italy. Electronic address: guidogembillo@live.it.<br /><searchLink fieldCode="AU" term="%22Bruschetta+G%22">Bruschetta G</searchLink>; Department of Veterinary Sciences, University of Messina, Messina 98168, Italy. Electronic address: giuseppe.bruschetta@unime.it.<br /><searchLink fieldCode="AU" term="%22Villalta+Savedra+E%22">Villalta Savedra E</searchLink>; Independent Researcher, Castrolibero 87040, Italy. Electronic address: edlinvillalta@gmail.com.<br /><searchLink fieldCode="AU" term="%22Lattanzio+F%22">Lattanzio F</searchLink>; Scientific Direction, Italian National Research Center on Aging (IRCCS INRCA), Ancona 60124, Italy. Electronic address: f.lattanzio@inrca.it.<br /><searchLink fieldCode="AU" term="%22Corsonello+A%22">Corsonello A</searchLink>; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende 87036, Italy; Unit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: a.corsonello@inrca.it.<br /><searchLink fieldCode="AU" term="%22Soraci+L%22">Soraci L</searchLink>; Unit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), Cosenza 87100, Italy. Electronic address: l.soraci@inrca.it.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 Jun; Vol. 199, pp. 119326. <i>Date of Electronic Publication: </i>2026 Apr 28.
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