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Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression.

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Title: Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression.
Authors: Hoover PJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Eisenhaure TM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Hodgin J; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Apruzzese W; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Mears J; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Peters M; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Jones T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Shah SI; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Kamal H; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Leavitt R; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Jackson SW; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, Washington, USA., Danaher P; Bruker Spatial Biology, Seattle, Washington, USA., Rao DA; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Xiao Q; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Gurajala S; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ai J; Department of Medicine, University of Chicago, Chicago, Illinois, USA., Fava A; Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, USA., Berthier CC; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Horisberger A; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Barnas JL; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA., Izmirly PM; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York, USA., Belmont HM; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York, USA., Clancy R; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York, USA., Furie R; The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA., Aranow C; The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA., Guthridge JM; Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Dall'Era M; Department of Medicine, University of California San Francisco, San Francisco, California, USA., Wofsy D; Department of Medicine, University of California San Francisco, San Francisco, California, USA., Kamen DL; Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Kalunian KC; Division of Rheumatology, Autoimmunity, and Inflammation, University of California San Diego School of Medicine, La Jolla, California, USA., McMahon MA; Department of Medicine, University of California Los Angeles, Los Angeles, California, USA., Grossman J; Department of Medicine, University of California Los Angeles, Los Angeles, California, USA., Payan-Schober F; Department of Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA., Hildeman DA; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Woodle ES; Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Putterman C; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA., Kretzler M; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Clark MR; Department of Medicine, University of Chicago, Chicago, Illinois, USA., Raychaudhuri S; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., James JA; Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Anolik JH; Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA., Petri MA; Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, USA., Buyon JP; Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York, USA., Diamond B; The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA., Davidson A; The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Arazi A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA. Electronic address: aarazi@northwell.edu.
Corporate Authors: Accelerating Medicines Partnership (AMP) RA/SLE Network
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2026 Jul; Vol. 85 (7), pp. 1324-1340. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
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