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GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.

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Title: GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
Authors: Liskiewicz D; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany.; Institute of Physiotherapy and Health Sciences, Academy of Physical Education, Katowice, Poland., Novikoff A; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Khalil A; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Akindehin S; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Campbell JE; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.; Duke Molecular Physiology Institute, Department of Medicine, Division of Endocrinology, Duke University, Durham, NC, USA., Candela P; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université Artois, Lens, France., Castelino RL; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Coupland C; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Culot M; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université Artois, Lens, France., Dodson WS; Indiana Biosciences Research Institute, Indianapolis, IN, USA., Douros JD; Indiana Biosciences Research Institute, Indianapolis, IN, USA.; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Embring H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Feuchtinger A; Core Facility Pathology and Tissue Analytics, Helmholtz, Munich, Germany., Finan B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Garcia-Caceres C; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany.; Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany., Gao XB; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Gosselet F; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université Artois, Lens, France., Grandl G; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Gutgesell RM; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany.; Institute of Computational Biology, Helmholtz Munich, Munich, Germany., Haas DT; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Jastroch M; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Karaoglu E; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany.; Department of Pharmacology, Experimental Therapy and Toxicology, Institute for Experimental and Clinical Pharmacology and Pharmacogenomic, Eberhard Karls University, Interfaculty Center of Pharmacogenomic and Drug Research, Tübingen, Germany., Kakimoto P; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Kaltenbach AC; Institute for Cardiovascular Prevention (IPEK), University Hospital, LMU Munich, Munich, Germany., Keuper M; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Kusminski CM; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Leander DC; Duke Molecular Physiology Institute, Department of Medicine, Division of Endocrinology, Duke University, Durham, NC, USA., Liskiewicz A; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany.; Department of Physiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland., Liu X; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Maity-Kumar G; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Martinez SM; CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Mowery SA; Indiana Biosciences Research Institute, Indianapolis, IN, USA.; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Nogueiras R; CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Paisley M; Duke Molecular Physiology Institute, Department of Medicine, Division of Endocrinology, Duke University, Durham, NC, USA., Perez-Tilve D; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Petersen PSS; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pfluger PT; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany.; Research Unit Neurobiology of Diabetes, Helmholtz Munich, Neuherberg, Germany.; Division of NeuroBiology of Diabetes, TUM School of Medicine and Health, Technical University Munich, Munich, Germany., Prakash S; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Steffens S; Institute for Cardiovascular Prevention (IPEK), University Hospital, LMU Munich, Munich, Germany.; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München (Helmholtz Munich), Munich, Germany.; DZHK (German Centre for Cardiovascular Research) Partner Site, Munich Heart Alliance, Munich, Germany., Cebrian-Serrano A; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany., Tost M; Core Facility Pathology and Tissue Analytics, Helmholtz, Munich, Germany., Wean J; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Weber C; Institute for Cardiovascular Prevention (IPEK), University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research) Partner Site, Munich Heart Alliance, Munich, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Yoshida J; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Gerhart-Hines Z; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Horvath TL; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest, Hungary., Scherer PE; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Seeley RJ; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., DiMarchi RD; Department of Chemistry, Indiana University, Bloomington, IN, USA., Tschöp MH; Helmholtz Munich, Munich, Germany.; Ludwig-Maximilians-University (LMU) Munich, Munich, Germany., Krahmer N; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany.; German Center for Diabetes Research (DZD), Munich, Germany.; Metabolic Cell Architecture, Department of Molecular Life Sciences, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Knerr PJ; Indiana Biosciences Research Institute, Indianapolis, IN, USA.; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Müller TD; Institute for Diabetes and Obesity, Helmholtz, Munich, Germany. timodirk.mueller@helmholtz-munich.de.; German Center for Diabetes Research (DZD), Munich, Germany. timodirk.mueller@helmholtz-munich.de.; Walther-Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. timodirk.mueller@helmholtz-munich.de.
Source: Nature [Nature] 2026 May; Vol. 653 (8115), pp. 776-785. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
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      – PersonEntity:
          Name:
            NameFull: Steffens S
      – PersonEntity:
          Name:
            NameFull: Cebrian-Serrano A
      – PersonEntity:
          Name:
            NameFull: Tost M
      – PersonEntity:
          Name:
            NameFull: Wean J
      – PersonEntity:
          Name:
            NameFull: Weber C
      – PersonEntity:
          Name:
            NameFull: Yoshida J
      – PersonEntity:
          Name:
            NameFull: Gerhart-Hines Z
      – PersonEntity:
          Name:
            NameFull: Horvath TL
      – PersonEntity:
          Name:
            NameFull: Scherer PE
      – PersonEntity:
          Name:
            NameFull: Seeley RJ
      – PersonEntity:
          Name:
            NameFull: DiMarchi RD
      – PersonEntity:
          Name:
            NameFull: Tschöp MH
      – PersonEntity:
          Name:
            NameFull: Krahmer N
      – PersonEntity:
          Name:
            NameFull: Knerr PJ
      – PersonEntity:
          Name:
            NameFull: Müller TD
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 653
            – Type: issue
              Value: 8115
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1