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Multi-omics analysis of pediatric minimally differentiated acute myeloid leukemia reveals RUNX1-driven stemness and chemoresistance.

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Title: Multi-omics analysis of pediatric minimally differentiated acute myeloid leukemia reveals RUNX1-driven stemness and chemoresistance.
Authors: Kamitori T; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan., Saida S; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. satoshi@kuhp.kyoto-u.ac.jp., Mitani K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Tsujimoto S; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., Goto H; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan., Shibata H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Akazawa R; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Isobe K; Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan., Ueno H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kakiuchi N; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan., Saito AM; Clinical Research Center, NHO Nagoya Medical Center, Nagoya, Japan., Hiwatari M; Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan., Kudo K; Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Hirabayashi S; Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan., Fukuoka K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan., Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan., Taga T; Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan., Kubota H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kato I; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Umeda K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Adachi S; Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kawai T; Department of Maternal Fetal Biology, National Center for Child Health and Development, Tokyo, Japan., Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan., Ikeda J; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., Shiba N; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan., Hayashi Y; Gunma Children's Medical Center, Shibukawa, Japan., Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.; Department of Innovative Medicine, Faculty of Medicine, Kindai University, Osaka, Japan., Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. jtakita@kuhp.kyoto-u.ac.jp.
Source: Leukemia [Leukemia] 2026 Apr 29. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: Multi-omics analysis of pediatric minimally differentiated acute myeloid leukemia reveals RUNX1-driven stemness and chemoresistance.
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  Data: <searchLink fieldCode="AU" term="%22Kamitori+T%22">Kamitori T</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Saida+S%22">Saida S</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. satoshi@kuhp.kyoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Mitani+K%22">Mitani K</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Tsujimoto+S%22">Tsujimoto S</searchLink>; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Goto+H%22">Goto H</searchLink>; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Shibata+H%22">Shibata H</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Akazawa+R%22">Akazawa R</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Isobe+K%22">Isobe K</searchLink>; Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ueno+H%22">Ueno H</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kakiuchi+N%22">Kakiuchi N</searchLink>; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+AM%22">Saito AM</searchLink>; Clinical Research Center, NHO Nagoya Medical Center, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Hiwatari+M%22">Hiwatari M</searchLink>; Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kudo+K%22">Kudo K</searchLink>; Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.<br /><searchLink fieldCode="AU" term="%22Hirabayashi+S%22">Hirabayashi S</searchLink>; Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuoka+K%22">Fukuoka K</searchLink>; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Koh+K%22">Koh K</searchLink>; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Taga+T%22">Taga T</searchLink>; Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.<br /><searchLink fieldCode="AU" term="%22Kubota+H%22">Kubota H</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+I%22">Kato I</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Umeda+K%22">Umeda K</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Adachi+S%22">Adachi S</searchLink>; Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai+T%22">Kawai T</searchLink>; Department of Maternal Fetal Biology, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tomizawa+D%22">Tomizawa D</searchLink>; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ikeda+J%22">Ikeda J</searchLink>; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Shiba+N%22">Shiba N</searchLink>; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+Y%22">Hayashi Y</searchLink>; Gunma Children's Medical Center, Shibukawa, Japan.<br /><searchLink fieldCode="AU" term="%22Ogawa+S%22">Ogawa S</searchLink>; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.; Department of Innovative Medicine, Faculty of Medicine, Kindai University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takita+J%22">Takita J</searchLink>; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. jtakita@kuhp.kyoto-u.ac.jp.
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