Crosstalk between integrin signaling and NAD⁺ biosynthetic pathways promotes glycolysis, proliferation, survival, and tumor growth in triple-negative breast cancer.

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Title: Crosstalk between integrin signaling and NAD⁺ biosynthetic pathways promotes glycolysis, proliferation, survival, and tumor growth in triple-negative breast cancer.
Authors: Spellecy O; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Qadir J; Sunnybrook Research Institute, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Han R; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA.; Department of Oncology, the Fourth Affiliated Hospital, Nanjing Medical University, Nanjing, China., Zhu K; College of Food Science and Technology, Shanghai Ocean University, Shanghai, China., Xu B; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Zhang Y; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA.; Department of Respiratory Medicine, First Affiliated Hospital of Soochow University, Suzhou, China., Aryal I; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Lin RL; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Lin AH; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Faisal ASM; Markey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA., Napier D; Markey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA., Piecoro D; Department of Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Scott T; Markey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA., Lin P; Markey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA., Chen L; Markey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA., Brewer LD; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Wang C; Markey Cancer Center and Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA., Kyprianou N; Tisch Cancer Institute, Icahn School of Medicine, The Mount Sinai Hospital, New York, NY, USA., Guo Z; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Guo R; College of Food Science and Technology, Shanghai Ocean University, Shanghai, China. rhguo@shou.edu.cn., Thibault O; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA. othibau@uky.edu., Yang BB; Sunnybrook Research Institute, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. byang@sri.utoronto.ca., Yang XH; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA. xya222@uky.edu.
Source: Oncogene [Oncogene] 2026 Jul; Vol. 45 (24), pp. 2327-2341. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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