View in EDS

Safety and antitumour activity of ipatasertib combined with endocrine therapy and a CDK4/6 inhibitor in HR+/HER2- metastatic breast cancer (TAKTIC): a single-centre, open-label, phase 1b trial.

Saved in:
Bibliographic Details
Title: Safety and antitumour activity of ipatasertib combined with endocrine therapy and a CDK4/6 inhibitor in HR+/HER2- metastatic breast cancer (TAKTIC): a single-centre, open-label, phase 1b trial.
Authors: Wander SA; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. Electronic address: swander@mgh.harvard.edu., Lloyd MR; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Keenan JC; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Scott EC; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Niemierko A; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Spring LM; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Fell GG; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Shin J; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Isakoff SJ; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Moy B; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Ryan L; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Padden S; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Fisher E; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Newton A; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Habin KR; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Viscosi-Spieler ET; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Scarpetti L; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Varkaris A; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Ellisen LW; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Dubash T; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Che D; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Patel PS; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., de la Cruz FF; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Sutaria DS; Genentech, South San Francisco, CA, USA., Sane RS; Genentech, South San Francisco, CA, USA., Micalizzi DS; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Maheswaran S; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Haber DA; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Juric D; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA., Bardia A; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Source: The Lancet. Oncology [Lancet Oncol] 2026 May; Vol. 27 (5), pp. 580-591.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42061370
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Safety and antitumour activity of ipatasertib combined with endocrine therapy and a CDK4/6 inhibitor in HR+/HER2- metastatic breast cancer (TAKTIC): a single-centre, open-label, phase 1b trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wander+SA%22">Wander SA</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. Electronic address: swander@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Lloyd+MR%22">Lloyd MR</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Keenan+JC%22">Keenan JC</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scott+EC%22">Scott EC</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Niemierko+A%22">Niemierko A</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Spring+LM%22">Spring LM</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fell+GG%22">Fell GG</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shin+J%22">Shin J</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Isakoff+SJ%22">Isakoff SJ</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Moy+B%22">Moy B</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ryan+L%22">Ryan L</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Padden+S%22">Padden S</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fisher+E%22">Fisher E</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Newton+A%22">Newton A</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Habin+KR%22">Habin KR</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Viscosi-Spieler+ET%22">Viscosi-Spieler ET</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scarpetti+L%22">Scarpetti L</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Varkaris+A%22">Varkaris A</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ellisen+LW%22">Ellisen LW</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dubash+T%22">Dubash T</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Che+D%22">Che D</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+PS%22">Patel PS</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22de+la+Cruz+FF%22">de la Cruz FF</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sutaria+DS%22">Sutaria DS</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sane+RS%22">Sane RS</searchLink>; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Micalizzi+DS%22">Micalizzi DS</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Maheswaran+S%22">Maheswaran S</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haber+DA%22">Haber DA</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Juric+D%22">Juric D</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bardia+A%22">Bardia A</searchLink>; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2026 May; Vol. 27 (5), pp. 580-591.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial, Phase I
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42061370
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S1470-2045(26)00059-8
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 580
    Titles:
      – TitleFull: Safety and antitumour activity of ipatasertib combined with endocrine therapy and a CDK4/6 inhibitor in HR+/HER2- metastatic breast cancer (TAKTIC): a single-centre, open-label, phase 1b trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wander SA
      – PersonEntity:
          Name:
            NameFull: Lloyd MR
      – PersonEntity:
          Name:
            NameFull: Keenan JC
      – PersonEntity:
          Name:
            NameFull: Scott EC
      – PersonEntity:
          Name:
            NameFull: Niemierko A
      – PersonEntity:
          Name:
            NameFull: Spring LM
      – PersonEntity:
          Name:
            NameFull: Fell GG
      – PersonEntity:
          Name:
            NameFull: Shin J
      – PersonEntity:
          Name:
            NameFull: Isakoff SJ
      – PersonEntity:
          Name:
            NameFull: Moy B
      – PersonEntity:
          Name:
            NameFull: Ryan L
      – PersonEntity:
          Name:
            NameFull: Padden S
      – PersonEntity:
          Name:
            NameFull: Fisher E
      – PersonEntity:
          Name:
            NameFull: Newton A
      – PersonEntity:
          Name:
            NameFull: Habin KR
      – PersonEntity:
          Name:
            NameFull: Viscosi-Spieler ET
      – PersonEntity:
          Name:
            NameFull: Scarpetti L
      – PersonEntity:
          Name:
            NameFull: Varkaris A
      – PersonEntity:
          Name:
            NameFull: Ellisen LW
      – PersonEntity:
          Name:
            NameFull: Dubash T
      – PersonEntity:
          Name:
            NameFull: Che D
      – PersonEntity:
          Name:
            NameFull: Patel PS
      – PersonEntity:
          Name:
            NameFull: de la Cruz FF
      – PersonEntity:
          Name:
            NameFull: Sutaria DS
      – PersonEntity:
          Name:
            NameFull: Sane RS
      – PersonEntity:
          Name:
            NameFull: Micalizzi DS
      – PersonEntity:
          Name:
            NameFull: Maheswaran S
      – PersonEntity:
          Name:
            NameFull: Haber DA
      – PersonEntity:
          Name:
            NameFull: Juric D
      – PersonEntity:
          Name:
            NameFull: Bardia A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1474-5488
          Numbering:
            – Type: volume
              Value: 27
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: The Lancet. Oncology
              Type: main
ResultId 1