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Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade.

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Title: Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade.
Authors: Sun JL; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Chu YC; Key Laboratory of Smart Drug Delivery Ministry of Education, Minhang Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China., Wang F; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Yu DD; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510100, China., Liu JR; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Xu RC; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Liu HH; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Qi ZR; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Shi X; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Yu XN; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Yao YK; Shanghai Institute of Nutrition & Health, Chinese Academy of Science, Shanghai 200031, China., Liu TT; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Weng SQ; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Dong L; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Shen XZ; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China., Hu SB; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China. Electronic address: hsb@ism.pumc.edu.cn., Sun T; Key Laboratory of Smart Drug Delivery Ministry of Education, Minhang Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: sunt@fudan.edu.cn., Zhu JM; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China. Electronic address: zhu.jimin@zs-hospital.sh.cn.
Source: Cell reports. Medicine [Cell Rep Med] 2026 May 19; Vol. 7 (5), pp. 102774. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade.
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  Data: <searchLink fieldCode="AU" term="%22Sun+JL%22">Sun JL</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Chu+YC%22">Chu YC</searchLink>; Key Laboratory of Smart Drug Delivery Ministry of Education, Minhang Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Yu+DD%22">Yu DD</searchLink>; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510100, China.<br /><searchLink fieldCode="AU" term="%22Liu+JR%22">Liu JR</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Xu+RC%22">Xu RC</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Liu+HH%22">Liu HH</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Qi+ZR%22">Qi ZR</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Shi+X%22">Shi X</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Yu+XN%22">Yu XN</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Yao+YK%22">Yao YK</searchLink>; Shanghai Institute of Nutrition & Health, Chinese Academy of Science, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Liu+TT%22">Liu TT</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Weng+SQ%22">Weng SQ</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Dong+L%22">Dong L</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Shen+XZ%22">Shen XZ</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Hu+SB%22">Hu SB</searchLink>; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China. Electronic address: hsb@ism.pumc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+T%22">Sun T</searchLink>; Key Laboratory of Smart Drug Delivery Ministry of Education, Minhang Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: sunt@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhu+JM%22">Zhu JM</searchLink>; Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China. Electronic address: zhu.jimin@zs-hospital.sh.cn.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2026 May 19; Vol. 7 (5), pp. 102774. <i>Date of Electronic Publication: </i>2026 Apr 29.
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