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Early antiretroviral therapy shapes the immunometabolic landscape without reducing the intact HIV reservoir.

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Title: Early antiretroviral therapy shapes the immunometabolic landscape without reducing the intact HIV reservoir.
Authors: Suanzes P; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain., Grau-Expósito J; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Navarro J; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Chafino S; Institut de Recerca Biomèdica Catalunya Sud, Hospital Universitari de Tarragona Joan XXIII (HJ23), Tarragona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Rull A; Institut de Recerca Biomèdica Catalunya Sud, Hospital Universitari de Tarragona Joan XXIII (HJ23), Tarragona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Rando-Segura A; Microbiology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Álvarez-López P; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Descalzo V; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., García JN; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Monforte A; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Curran A; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Burgos J; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Planas B; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Sanchiz M; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Genescà M; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain., Falcó V; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain., Buzón MJ; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: mariajose.buzon@vhir.org.
Source: The Journal of infection [J Infect] 2026 Jun; Vol. 92 (6), pp. 106754. Date of Electronic Publication: 2026 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early antiretroviral therapy shapes the immunometabolic landscape without reducing the intact HIV reservoir.
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  Data: <searchLink fieldCode="AU" term="%22Suanzes+P%22">Suanzes P</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Grau-Expósito+J%22">Grau-Expósito J</searchLink>; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Navarro+J%22">Navarro J</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Chafino+S%22">Chafino S</searchLink>; Institut de Recerca Biomèdica Catalunya Sud, Hospital Universitari de Tarragona Joan XXIII (HJ23), Tarragona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rull+A%22">Rull A</searchLink>; Institut de Recerca Biomèdica Catalunya Sud, Hospital Universitari de Tarragona Joan XXIII (HJ23), Tarragona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rando-Segura+A%22">Rando-Segura A</searchLink>; Microbiology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Álvarez-López+P%22">Álvarez-López P</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Descalzo+V%22">Descalzo V</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García+JN%22">García JN</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Monforte+A%22">Monforte A</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Curran+A%22">Curran A</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Burgos+J%22">Burgos J</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Planas+B%22">Planas B</searchLink>; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sanchiz+M%22">Sanchiz M</searchLink>; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Genescà+M%22">Genescà M</searchLink>; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Falcó+V%22">Falcó V</searchLink>; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Buzón+MJ%22">Buzón MJ</searchLink>; Infectious Diseases Department, Vall d'Hebron Institut de Recerca (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: mariajose.buzon@vhir.org.
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  Data: <searchLink fieldCode="JN" term="%227908424%22">The Journal of infection</searchLink> [J Infect] 2026 Jun; Vol. 92 (6), pp. 106754. <i>Date of Electronic Publication: </i>2026 Apr 28.
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