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Genome-Wide Meta-Analysis for High Myopia Provides Insights into Disease Mechanisms and Reveals a Causal Link to Primary Open-Angle Glaucoma.

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Title: Genome-Wide Meta-Analysis for High Myopia Provides Insights into Disease Mechanisms and Reveals a Causal Link to Primary Open-Angle Glaucoma.
Authors: Morino K; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Meguro A; Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Nagasaki M; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Division of Biomedical Information Analysis, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Motoike IN; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Numa S; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mori Y; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Yasukura S; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Akada M; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakao SY; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kamei T; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Nakata A; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Takeuchi M; Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Yamada N; Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Mizuki Y; Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Yoshida T; Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Kamatani Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Anzawa H; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kinoshita K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Ohno-Matsui K; Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan., Fuse N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Tsujikawa A; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mizuki N; Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Miyake M; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Corporate Authors: Nagahama Study Group
Source: Ophthalmology science [Ophthalmol Sci] 2026 Mar 19; Vol. 6 (6), pp. 101165. Date of Electronic Publication: 2026 Mar 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 9918230896206676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-9145 (Electronic) Linking ISSN: 26669145 NLM ISO Abbreviation: Ophthalmol Sci Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Morino+K%22">Morino K</searchLink>; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Meguro+A%22">Meguro A</searchLink>; Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Nagasaki+M%22">Nagasaki M</searchLink>; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Division of Biomedical Information Analysis, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Motoike+IN%22">Motoike IN</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Akiyama+M%22">Akiyama M</searchLink>; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Kawaguchi+T%22">Kawaguchi T</searchLink>; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Numa+S%22">Numa S</searchLink>; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Mori+Y%22">Mori Y</searchLink>; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; 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Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Tsujikawa+A%22">Tsujikawa A</searchLink>; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuki+N%22">Mizuki N</searchLink>; Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Miyake+M%22">Miyake M</searchLink>; Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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