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Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.

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Title: Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.
Authors: Chen G; Epidemiology and Public Health Group, School of Health Sciences, The University of Manchester, Manchester, UK., Zhao SS; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Chinoy H; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, UK., Lilleker JB; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Manchester Centre for Clinical Neuroscience, Manchester Academic Health Science Centre, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK., Liu W; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Li Y; Epidemiology and Public Health Group, School of Health Sciences, The University of Manchester, Manchester, UK; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Department of Rheumatology and Immunology and Beijing Key Laboratory for Rheumatism and Immune Diagnosis, Peking University People's Hospital, Beijing, China., Morris AP; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address: andrew.morris-5@manchester.ac.uk., Lamb JA; Epidemiology and Public Health Group, School of Health Sciences, The University of Manchester, Manchester, UK. Electronic address: janine.lamb@manchester.ac.uk.
Source: EBioMedicine [EBioMedicine] 2026 May; Vol. 127, pp. 106274. Date of Electronic Publication: 2026 Apr 30.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Epidemiology and Public Health Group, School of Health Sciences, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Zhao+SS%22">Zhao SS</searchLink>; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Chinoy+H%22">Chinoy H</searchLink>; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.<br /><searchLink fieldCode="AU" term="%22Lilleker+JB%22">Lilleker JB</searchLink>; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Manchester Centre for Clinical Neuroscience, Manchester Academic Health Science Centre, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Epidemiology and Public Health Group, School of Health Sciences, The University of Manchester, Manchester, UK; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Department of Rheumatology and Immunology and Beijing Key Laboratory for Rheumatism and Immune Diagnosis, Peking University People's Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Morris+AP%22">Morris AP</searchLink>; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address: andrew.morris-5@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Lamb+JA%22">Lamb JA</searchLink>; Epidemiology and Public Health Group, School of Health Sciences, The University of Manchester, Manchester, UK. Electronic address: janine.lamb@manchester.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2026 May; Vol. 127, pp. 106274. <i>Date of Electronic Publication: </i>2026 Apr 30.
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              Text: 2026 May
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