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Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis.

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Title: Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis.
Authors: Tang YJ; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China., Du X; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China., Yin B; Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China., Liu HY; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China., Tang YJ; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China., Zhang ZY; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China., Meng QM; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China., Zhang Y; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China., Deng JL; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China., Li Y; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China., Yang PL; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China., Kang K; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China. janekk79@126.com., Zhao MY; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China. mingyan0927@126.com., Gao Y; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China. gaoyang0312@126.com.
Source: Inflammation [Inflammation] 2026 May 02; Vol. 49 (1). Date of Electronic Publication: 2026 May 02.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Tang+YJ%22">Tang YJ</searchLink>; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Du+X%22">Du X</searchLink>; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yin+B%22">Yin B</searchLink>; Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+HY%22">Liu HY</searchLink>; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Tang+YJ%22">Tang YJ</searchLink>; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZY%22">Zhang ZY</searchLink>; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Meng+QM%22">Meng QM</searchLink>; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Deng+JL%22">Deng JL</searchLink>; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+PL%22">Yang PL</searchLink>; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Kang+K%22">Kang K</searchLink>; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China. janekk79@126.com.<br /><searchLink fieldCode="AU" term="%22Zhao+MY%22">Zhao MY</searchLink>; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang Province, People's Republic of China. mingyan0927@126.com.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Songbei District, Harbin, 150027, Heilongjiang Province, People's Republic of China. gaoyang0312@126.com.
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        Value: 10.1007/s10753-026-02495-6
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        Text: English
    Titles:
      – TitleFull: Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis.
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              Text: 2026 May 02
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