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ALS-FTD-linked CCNFS621G drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability.

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Title: ALS-FTD-linked CCNFS621G drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability.
Authors: Robinson L; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia., Do-Ha D; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia., Cheng F; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia., Stevens CH; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia., Rosa Porto R; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia., Coles M; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia., Subachandran J; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia., Kalajdzic P; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, 2145, Australia., Lui J; Faculty of Medicine and Health, School of Medical Sciences, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia., Balez R; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia., Sanz Muñoz S; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia., Cabral-da-Silva MC; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia., Berg T; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia., Morsch M; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia., Lisowski L; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, 2145, Australia.; Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine - National Research Institute, Warsaw, 04-141, Poland., Tan RH; Faculty of Medicine and Health, School of Medical Sciences, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia., Burgio G; Division of Genome Sciences and Cancer, The Shine Dalgarno Centre for RNA Innovation, the John Curtin School of Medical Research, The Australian National University, Canberra, Australia., Karl T; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia., Lee A; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia., Chung RS; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia., Blair I; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia., Ooi L; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia. lezanne@uow.edu.au.
Source: Journal of neuroinflammation [J Neuroinflammation] 2026 May 02. Date of Electronic Publication: 2026 May 02.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: ALS-FTD-linked CCNF<superscript>S621G</superscript> drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability.
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  Data: <searchLink fieldCode="AU" term="%22Robinson+L%22">Robinson L</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Do-Ha+D%22">Do-Ha D</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cheng+F%22">Cheng F</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Stevens+CH%22">Stevens CH</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Rosa+Porto+R%22">Rosa Porto R</searchLink>; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.<br /><searchLink fieldCode="AU" term="%22Coles+M%22">Coles M</searchLink>; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.<br /><searchLink fieldCode="AU" term="%22Subachandran+J%22">Subachandran J</searchLink>; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.<br /><searchLink fieldCode="AU" term="%22Kalajdzic+P%22">Kalajdzic P</searchLink>; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Lui+J%22">Lui J</searchLink>; Faculty of Medicine and Health, School of Medical Sciences, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Balez+R%22">Balez R</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sanz+Muñoz+S%22">Sanz Muñoz S</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cabral-da-Silva+MC%22">Cabral-da-Silva MC</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Berg+T%22">Berg T</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Morsch+M%22">Morsch M</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Lisowski+L%22">Lisowski L</searchLink>; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, 2145, Australia.; Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine - National Research Institute, Warsaw, 04-141, Poland.<br /><searchLink fieldCode="AU" term="%22Tan+RH%22">Tan RH</searchLink>; Faculty of Medicine and Health, School of Medical Sciences, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Burgio+G%22">Burgio G</searchLink>; Division of Genome Sciences and Cancer, The Shine Dalgarno Centre for RNA Innovation, the John Curtin School of Medical Research, The Australian National University, Canberra, Australia.<br /><searchLink fieldCode="AU" term="%22Karl+T%22">Karl T</searchLink>; School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+A%22">Lee A</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Chung+RS%22">Chung RS</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Blair+I%22">Blair I</searchLink>; Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine Health and Human Sciences, Macquarie University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Ooi+L%22">Ooi L</searchLink>; School of Science and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia. lezanne@uow.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101222974%22">Journal of neuroinflammation</searchLink> [J Neuroinflammation] 2026 May 02. <i>Date of Electronic Publication: </i>2026 May 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101222974 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1742-2094 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217422094%22">17422094 </searchLink><i>NLM ISO Abbreviation: </i>J Neuroinflammation <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12974-026-03827-x
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        Text: English
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      – TitleFull: ALS-FTD-linked CCNFS621G drives increased hippocampal astrocyte ramification and mitochondrial dysfunction and impairs motor neuron excitability.
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              Text: 2026 May 02
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