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Structural optimization of benzophenanthridinone and benzophenanthridine Tyrosyl-DNA phosphodiesterase 1 inhibitors and their radiosensitizing activity.

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Title: Structural optimization of benzophenanthridinone and benzophenanthridine Tyrosyl-DNA phosphodiesterase 1 inhibitors and their radiosensitizing activity.
Authors: Hu DX; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Chengdu Medical College, Chengdu, 610500, China., Li YW; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Chen A; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Qin C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Institute for Drug Control, Guangzhou, 510663, China., Zhang JQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Liang ZQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Agama K; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States., Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States., Wang H; Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China. Electronic address: wanghm7@mail.sysu.edu.cn., An LK; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, 510006, China. Electronic address: lssalk@mail.sysu.edu.cn.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Sep 05; Vol. 313, pp. 118907. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural optimization of benzophenanthridinone and benzophenanthridine Tyrosyl-DNA phosphodiesterase 1 inhibitors and their radiosensitizing activity.
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  Data: <searchLink fieldCode="AU" term="%22Hu+DX%22">Hu DX</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Chengdu Medical College, Chengdu, 610500, China.<br /><searchLink fieldCode="AU" term="%22Li+YW%22">Li YW</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Chen+A%22">Chen A</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Qin+C%22">Qin C</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Institute for Drug Control, Guangzhou, 510663, China.<br /><searchLink fieldCode="AU" term="%22Zhang+JQ%22">Zhang JQ</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Liang+ZQ%22">Liang ZQ</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Agama+K%22">Agama K</searchLink>; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.<br /><searchLink fieldCode="AU" term="%22Pommier+Y%22">Pommier Y</searchLink>; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China. Electronic address: wanghm7@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22An+LK%22">An LK</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, 510006, China. Electronic address: lssalk@mail.sysu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Sep 05; Vol. 313, pp. 118907. <i>Date of Electronic Publication: </i>2026 Apr 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2026.118907
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              Text: 2026 Sep 05
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