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Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids.

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Title: Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids.
Authors: Song IS; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Kyungpook National University, Daegu 41566, Republic of Korea., Pang M; College of Pharmacy, Dankook University, Cheon-an 31116, Republic of Korea., Lee MS; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea., Lee J; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Kyungpook National University, Daegu 41566, Republic of Korea., Liu KH; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea., Choi MK; College of Pharmacy, Dankook University, Cheon-an 31116, Republic of Korea., Park HJ; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Kim H; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea., Lee HS; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Source: Pharmaceutics [Pharmaceutics] 2026 Apr 14; Vol. 18 (4). Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids.
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  Data: <searchLink fieldCode="AU" term="%22Song+IS%22">Song IS</searchLink>; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Kyungpook National University, Daegu 41566, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Pang+M%22">Pang M</searchLink>; College of Pharmacy, Dankook University, Cheon-an 31116, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+MS%22">Lee MS</searchLink>; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Kyungpook National University, Daegu 41566, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Liu+KH%22">Liu KH</searchLink>; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+MK%22">Choi MK</searchLink>; College of Pharmacy, Dankook University, Cheon-an 31116, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+HJ%22">Park HJ</searchLink>; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HS%22">Lee HS</searchLink>; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101534003%22">Pharmaceutics</searchLink> [Pharmaceutics] 2026 Apr 14; Vol. 18 (4). <i>Date of Electronic Publication: </i>2026 Apr 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI%22">MDPI </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101534003 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1999-4923 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219994923%22">19994923 </searchLink><i>NLM ISO Abbreviation: </i>Pharmaceutics <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.3390/pharmaceutics18040483
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      – Code: eng
        Text: English
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      – TitleFull: Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids.
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            – D: 14
              M: 04
              Text: 2026 Apr 14
              Type: published
              Y: 2026
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