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Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer.

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Title: Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer.
Authors: Fu R; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Wang Y; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Rehman I; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.; Department of Biotechnology, The Neotia University, Sarisha, West Bengal, 743368, India., Bedford E; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Sharif S; Department of Pharmacological and Pharmaceutical Sciences, The University of Houston College of Pharmacy, Houston, TX, 77204, USA., Nguyen ND; Texas A&M Health Center for Translational Cancer Research, Houston, TX, 77030, USA., Powell RT; Texas A&M Health Center for Translational Cancer Research, Houston, TX, 77030, USA., Adams A; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Liu W; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Wang S; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., He W; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Lu Y; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Liu B; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Shah PA; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Ahnert JR; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Chen T; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Peng W; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77004, USA., Stephan CC; Texas A&M Health Center for Translational Cancer Research, Houston, TX, 77030, USA., Liu X; Department of Pharmacological and Pharmaceutical Sciences, The University of Houston College of Pharmacy, Houston, TX, 77204, USA., Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA., Xu H; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 21. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Fu+R%22">Fu R</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Rehman+I%22">Rehman I</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.; Department of Biotechnology, The Neotia University, Sarisha, West Bengal, 743368, India.<br /><searchLink fieldCode="AU" term="%22Bedford+E%22">Bedford E</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Sharif+S%22">Sharif S</searchLink>; Department of Pharmacological and Pharmaceutical Sciences, The University of Houston College of Pharmacy, Houston, TX, 77204, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+ND%22">Nguyen ND</searchLink>; Texas A&M Health Center for Translational Cancer Research, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Powell+RT%22">Powell RT</searchLink>; Texas A&M Health Center for Translational Cancer Research, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Adams+A%22">Adams A</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22He+W%22">He W</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Shah+PA%22">Shah PA</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ahnert+JR%22">Ahnert JR</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Peng+W%22">Peng W</searchLink>; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77004, USA.<br /><searchLink fieldCode="AU" term="%22Stephan+CC%22">Stephan CC</searchLink>; Texas A&M Health Center for Translational Cancer Research, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Pharmacological and Pharmaceutical Sciences, The University of Houston College of Pharmacy, Houston, TX, 77204, USA.<br /><searchLink fieldCode="AU" term="%22Bedford+MT%22">Bedford MT</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
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