The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry.

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Title: The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry.
Authors: Suzuki N; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Yoshimi R; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan., Mizuno H; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Hidekawa C; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Sakurai N; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Yoshioka Y; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Kishimoto D; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Takase-Minegishi K; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Ohno S; Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan., Yajima N; Division of Rheumatology, Department of Medicine, Showa Medical University, Tokyo, Japan., Sada KE; Department of Clinical Epidemiology, Kochi Medical School, Kochi University, Nankoku, Japan.; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Miyawaki Y; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Ichinose K; Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan., Shimizu T; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Takatani A; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Rheumatic Disease Center, Sasebo Chuo Hospital, Sasebo, Japan., Kajiyama H; Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan., Sato S; Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan., Shimojima Y; Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan., Fujiwara M; Department of Rheumatology, Yokohama Rosai Hospital, Yokohama, Japan., Onishi A; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kida T; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Matsuo Y; Department of Rheumatology, Tokyo Kyosai Hospital, Tokyo, Japan.; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Nishimura K; Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan., Onishi T; Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan., Katsushima M; Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan., Umekita K; Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Miyake H; Department of General Internal Medicine, Tenri Hospital, Tenri, Japan., Nakano H; Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan., Ida T; Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan., Ikeda K; Department of Rheumatology, Dokkyo Medical University, Tochigi, Japan., Nakajima H; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Source: Frontiers in immunology [Front Immunol] 2026 Apr 16; Vol. 17, pp. 1781933. Date of Electronic Publication: 2026 Apr 16 (Print Publication: 2026).
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry.
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  Data: <searchLink fieldCode="AU" term="%22Suzuki+N%22">Suzuki N</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshimi+R%22">Yoshimi R</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuno+H%22">Mizuno H</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Hidekawa+C%22">Hidekawa C</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Sakurai+N%22">Sakurai N</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshioka+Y%22">Yoshioka Y</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Kishimoto+D%22">Kishimoto D</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Takase-Minegishi+K%22">Takase-Minegishi K</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ohno+S%22">Ohno S</searchLink>; Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yajima+N%22">Yajima N</searchLink>; Division of Rheumatology, Department of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sada+KE%22">Sada KE</searchLink>; Department of Clinical Epidemiology, Kochi Medical School, Kochi University, Nankoku, Japan.; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Miyawaki+Y%22">Miyawaki Y</searchLink>; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Ichinose+K%22">Ichinose K</searchLink>; Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Takatani+A%22">Takatani A</searchLink>; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Rheumatic Disease Center, Sasebo Chuo Hospital, Sasebo, Japan.<br /><searchLink fieldCode="AU" term="%22Kajiyama+H%22">Kajiyama H</searchLink>; Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+S%22">Sato S</searchLink>; Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan.<br /><searchLink fieldCode="AU" term="%22Shimojima+Y%22">Shimojima Y</searchLink>; Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.<br /><searchLink fieldCode="AU" term="%22Fujiwara+M%22">Fujiwara M</searchLink>; Department of Rheumatology, Yokohama Rosai Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Onishi+A%22">Onishi A</searchLink>; Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kida+T%22">Kida T</searchLink>; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuo+Y%22">Matsuo Y</searchLink>; Department of Rheumatology, Tokyo Kyosai Hospital, Tokyo, Japan.; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+K%22">Nishimura K</searchLink>; Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Onishi+T%22">Onishi T</searchLink>; Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan.<br /><searchLink fieldCode="AU" term="%22Katsushima+M%22">Katsushima M</searchLink>; Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Umekita+K%22">Umekita K</searchLink>; Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.<br /><searchLink fieldCode="AU" term="%22Miyake+H%22">Miyake H</searchLink>; Department of General Internal Medicine, Tenri Hospital, Tenri, Japan.<br /><searchLink fieldCode="AU" term="%22Nakano+H%22">Nakano H</searchLink>; Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ida+T%22">Ida T</searchLink>; Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Ikeda+K%22">Ikeda K</searchLink>; Department of Rheumatology, Dokkyo Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Nakajima+H%22">Nakajima H</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
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