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Randomised controlled trial comparing antibiotic cement bead pouch versus negative pressure wound therapy for the management of severe open tibia fracture wounds: Beads versus VAC (BvV) protocol.

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Title: Randomised controlled trial comparing antibiotic cement bead pouch versus negative pressure wound therapy for the management of severe open tibia fracture wounds: Beads versus VAC (BvV) protocol.
Authors: Marchand LS; Department of Orthopaedic Surgery, University of Utah, Salt Lake City, Utah, USA lucas.marchand@hsc.utah.edu., Slobogean G; Department of Orthopedic Surgery, University of California, Irvine, Orange, California, USA., O'Hara NN; Department of Orthopaedics, University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Center for Orthopaedic Injury Research and Innovation, Baltimore, Maryland, USA., Harris AD; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Grainger DW; Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA., Thabane L; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Bhandari M; Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Della Rocca GJ; Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, USA., Kellam PJ; Department of Orthopedic Surgery, McGovern Medical School at UTHealth Houston, Houston, Texas, USA., Zura RD; LSUHSC Orthopaedics New Orleans, New Orleans, Louisiana, USA., Marvel D; Patient Representative, University of Maryland Baltimore, Baltimore, Maryland, USA., Wells JL; Patient Representative, University of Maryland Baltimore, Baltimore, Maryland, USA., Gitajn IL; Department of Orthopaedic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA., Jeray KJ; Department of Orthopedic Surgery, Prisma Health-Upstate, University of South Carolina, Greenville, South Carolina, USA., O'Toole RV; Department of Orthopaedics, University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Center for Orthopaedic Injury Research and Innovation, Baltimore, Maryland, USA., Working ZM; Department of Orthopaedics & Rehabilitation, Oregon Health & Science University, Portland, Oregon, USA., Natoli RM; Division of Orthopaedic Trauma, Department of Orthopaedic Surgery, IU Methodist Hospital, Indianapolis, Indiana, USA., Bergin PF; Department of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, Mississippi, USA., Hagen JE; Division of Orthopaedic Trauma, Department of Orthopaedic Surgery and Sports Medicine, University of Florida, Gainesville, Florida, USA., Levack AE; Department of Orthopaedic Surgery & Rehabilitation, Loyola University Medical Center & Stritch School of Medicine, Maywood, Illinois, USA., Guerra-Farfan E; Department of Orthopedic Surgery and Traumatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Schrank GM; Division of Infectious Disease, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Hebden JN; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Mossuto F; Division of Orthopaedic Surgery, Hamilton Health Sciences Hospital, General Site, Hamilton, Ontario, Canada., Tsoutsounakis C; University of Utah Hospital, Salt Lake City, Utah, USA., Pogorzelski D; Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Pineda H; Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Bzovsky S; Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Sprague S; Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.; Department of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
Corporate Authors: BvV Investigators
Source: BMJ open [BMJ Open] 2026 May 04; Vol. 16 (5), pp. e088521. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Randomised controlled trial comparing antibiotic cement bead pouch versus negative pressure wound therapy for the management of severe open tibia fracture wounds: Beads versus VAC (BvV) protocol.
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  Data: <searchLink fieldCode="AU" term="%22Marchand+LS%22">Marchand LS</searchLink>; Department of Orthopaedic Surgery, University of Utah, Salt Lake City, Utah, USA lucas.marchand@hsc.utah.edu.<br /><searchLink fieldCode="AU" term="%22Slobogean+G%22">Slobogean G</searchLink>; Department of Orthopedic Surgery, University of California, Irvine, Orange, California, USA.<br /><searchLink fieldCode="AU" term="%22O'Hara+NN%22">O'Hara NN</searchLink>; Department of Orthopaedics, University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Center for Orthopaedic Injury Research and Innovation, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Harris+AD%22">Harris AD</searchLink>; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Grainger+DW%22">Grainger DW</searchLink>; Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Thabane+L%22">Thabane L</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bhandari+M%22">Bhandari M</searchLink>; Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Della+Rocca+GJ%22">Della Rocca GJ</searchLink>; Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Kellam+PJ%22">Kellam PJ</searchLink>; Department of Orthopedic Surgery, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Zura+RD%22">Zura RD</searchLink>; LSUHSC Orthopaedics New Orleans, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Marvel+D%22">Marvel D</searchLink>; Patient Representative, University of Maryland Baltimore, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wells+JL%22">Wells JL</searchLink>; Patient Representative, University of Maryland Baltimore, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gitajn+IL%22">Gitajn IL</searchLink>; Department of Orthopaedic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.<br /><searchLink fieldCode="AU" term="%22Jeray+KJ%22">Jeray KJ</searchLink>; Department of Orthopedic Surgery, Prisma Health-Upstate, University of South Carolina, Greenville, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22O'Toole+RV%22">O'Toole RV</searchLink>; Department of Orthopaedics, University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, Center for Orthopaedic Injury Research and Innovation, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Working+ZM%22">Working ZM</searchLink>; Department of Orthopaedics & Rehabilitation, Oregon Health & Science University, Portland, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Natoli+RM%22">Natoli RM</searchLink>; Division of Orthopaedic Trauma, Department of Orthopaedic Surgery, IU Methodist Hospital, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Bergin+PF%22">Bergin PF</searchLink>; Department of Orthopaedic Surgery and Rehabilitation, University of Mississippi Medical Center, Jackson, Mississippi, USA.<br /><searchLink fieldCode="AU" term="%22Hagen+JE%22">Hagen JE</searchLink>; Division of Orthopaedic Trauma, Department of Orthopaedic Surgery and Sports Medicine, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Levack+AE%22">Levack AE</searchLink>; Department of Orthopaedic Surgery & Rehabilitation, Loyola University Medical Center & Stritch School of Medicine, Maywood, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Guerra-Farfan+E%22">Guerra-Farfan E</searchLink>; Department of Orthopedic Surgery and Traumatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Schrank+GM%22">Schrank GM</searchLink>; Division of Infectious Disease, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hebden+JN%22">Hebden JN</searchLink>; 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Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.; Department of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
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