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Transposable elements shape stemness in normal and leukemic hematopoiesis.

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Title: Transposable elements shape stemness in normal and leukemic hematopoiesis.
Authors: Grillo G; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; T-One Therapeutics, Milan, Italy., Nadorp B; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Bristol Myers Squibb, Princeton, NJ, USA., Qamra A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Hoffman-La Roche, Mississauga, Ontario, Canada., Drylie B; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.; Centre for Epigenetics, Queen Mary University of London, London, UK., Mitchell A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Arlidge C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Nand A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Takayama N; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Murison A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Madani Tonekaboni SA; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Kang KK; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Arruda A; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada., Wang JCY; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Deniz Ö; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.; Centre for Epigenetics, Queen Mary University of London, London, UK., Boutzen H; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. john.dick@uhn.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. john.dick@uhn.ca., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. mathieu.lupien@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. mathieu.lupien@uhn.ca.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada. mathieu.lupien@uhn.ca.
Source: Nature genetics [Nat Genet] 2026 May; Vol. 58 (5), pp. 1087-1099. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Grillo+G%22">Grillo G</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; T-One Therapeutics, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Nadorp+B%22">Nadorp B</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Bristol Myers Squibb, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Qamra+A%22">Qamra A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Hoffman-La Roche, Mississauga, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Drylie+B%22">Drylie B</searchLink>; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.; Centre for Epigenetics, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mitchell+A%22">Mitchell A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Arlidge+C%22">Arlidge C</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Nand+A%22">Nand A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Takayama+N%22">Takayama N</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Murison+A%22">Murison A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Madani+Tonekaboni+SA%22">Madani Tonekaboni SA</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kang+KK%22">Kang KK</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Arruda+A%22">Arruda A</searchLink>; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+JCY%22">Wang JCY</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Minden+MD%22">Minden MD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Deniz+Ö%22">Deniz Ö</searchLink>; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.; Centre for Epigenetics, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Boutzen+H%22">Boutzen H</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dick+JE%22">Dick JE</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. john.dick@uhn.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. john.dick@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Lupien+M%22">Lupien M</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. mathieu.lupien@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. mathieu.lupien@uhn.ca.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada. mathieu.lupien@uhn.ca.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2026 May; Vol. 58 (5), pp. 1087-1099. <i>Date of Electronic Publication: </i>2026 May 04.
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