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Predicting immunotherapy benefit in leiomyosarcoma through active chromatin cfDNA profiling.

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Title: Predicting immunotherapy benefit in leiomyosarcoma through active chromatin cfDNA profiling.
Authors: Lopes CDH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Sinai Health System, University Health Network, Toronto, ON, Canada., Wu HT; Aqtual, Hayward, CA, USA., Dilger K; Aqtual, Hayward, CA, USA., Zhang YW; Aqtual, Hayward, CA, USA., Salawu A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Sinai Health System, University Health Network, Toronto, ON, Canada., Stayner LA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Gupta AA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Hansen AR; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Spreafico A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Bedard PL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Louie MC; Aqtual, Hayward, CA, USA., Siu LL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Princess Margaret Cancer Consortium, Marathon of Hope Cancer Centres Network, Toronto, ON, Canada., Abdul Razak AR; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. albiruni.razak@uhn.ca.; Sinai Health System, University Health Network, Toronto, ON, Canada. albiruni.razak@uhn.ca.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Predicting immunotherapy benefit in leiomyosarcoma through active chromatin cfDNA profiling.
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  Data: <searchLink fieldCode="AU" term="%22Lopes+CDH%22">Lopes CDH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Sinai Health System, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wu+HT%22">Wu HT</searchLink>; Aqtual, Hayward, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dilger+K%22">Dilger K</searchLink>; Aqtual, Hayward, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+YW%22">Zhang YW</searchLink>; Aqtual, Hayward, CA, USA.<br /><searchLink fieldCode="AU" term="%22Salawu+A%22">Salawu A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Sinai Health System, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Stayner+LA%22">Stayner LA</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gupta+AA%22">Gupta AA</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hansen+AR%22">Hansen AR</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Spreafico+A%22">Spreafico A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bedard+PL%22">Bedard PL</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Louie+MC%22">Louie MC</searchLink>; Aqtual, Hayward, CA, USA.<br /><searchLink fieldCode="AU" term="%22Siu+LL%22">Siu LL</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Princess Margaret Cancer Consortium, Marathon of Hope Cancer Centres Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Abdul+Razak+AR%22">Abdul Razak AR</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. albiruni.razak@uhn.ca.; Sinai Health System, University Health Network, Toronto, ON, Canada. albiruni.razak@uhn.ca.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol
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        Value: 10.1038/s41698-026-01451-9
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              Text: 2026 May 05
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