Costimulation loss enhances IL-2-driven Treg generation by PI3K-STAT3 inhibition in CNS autoimmunity.

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Title: Costimulation loss enhances IL-2-driven Treg generation by PI3K-STAT3 inhibition in CNS autoimmunity.
Authors: Nam KH; Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea., Kim GR; Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea.; Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea., Kim YR; Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea., Kwon YN; Department of Neurology, Kangbuk Samsung Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea., Kim SM; Department of Neurology, Seoul National University, College of Medicine, Seoul, Republic of Korea., Choi JM; Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea. jeminchoi@hanyang.ac.kr.; Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea. jeminchoi@hanyang.ac.kr.; Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Republic of Korea. jeminchoi@hanyang.ac.kr.; Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul, Republic of Korea. jeminchoi@hanyang.ac.kr.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2272-2292. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-026-00431-7