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Posttranslational modifications remodel proteome-wide ligandability.

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Title: Posttranslational modifications remodel proteome-wide ligandability.
Authors: Li W; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Wei Q; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA., Llanos M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Gathmann C; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Governa P; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Chiu TY; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA., Wozniak JM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Jadhav AM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Holcomb M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Cravatt J; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Dongre A; Research and Development, Bristol Myers Squibb Company, Princeton, NJ, USA., Huang ML; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Parker CG; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cparker@scripps.edu.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA. cparker@scripps.edu.
Source: Nature chemical biology [Nat Chem Biol] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wei+Q%22">Wei Q</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Llanos+M%22">Llanos M</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gathmann+C%22">Gathmann C</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Governa+P%22">Governa P</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chiu+TY%22">Chiu TY</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wozniak+JM%22">Wozniak JM</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jadhav+AM%22">Jadhav AM</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Holcomb+M%22">Holcomb M</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cravatt+J%22">Cravatt J</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dongre+A%22">Dongre A</searchLink>; Research and Development, Bristol Myers Squibb Company, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Huang+ML%22">Huang ML</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Parker+CG%22">Parker CG</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cparker@scripps.edu.; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, CA, USA. cparker@scripps.edu.
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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2026 May 05. <i>Date of Electronic Publication: </i>2026 May 05.
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